Cochrane

Protocol: Primary aim:Through systematic review and meta-analysis (if appropriate), the primary aim of this study is to determine whether peritonectomy procedures with or without HIPEC confer a survival advantage to patients with PMP over repeated laparotomy and debulking ('standard' approach). Secondary aims:1. Determine the patterns and extent ...

Protocol: To determine the incidence of angioedema associated with ACE inhibitors versus placebo in the treatment of primary hypertension.

Women can develop mental health problems during pregnancy or at childbirth and over the following year. These problems range from depression (both minor and major), anxiety disorders, post-traumatic stress disorder to bipolar disorder, schizophrenia and psychosis (puerperal psychosis). Life stresses such as bereavement, separation, unemployment, illness, ...

Protocol: To examine the effectiveness of aquatic therapy interventions for treating rheumatoid arthritis when compared to "land" interventions (therapeutic exercises, home orientation) or no intervention.

The class of drugs called ACE inhibitors is commonly used for the treatment of elevated blood pressure. This class includes drugs such as ramipril (brand name: Altace), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril) and quinapril (Accupril). We asked how much this class of drugs lowers blood pressure ...

A class of drugs called angiotensin receptor blockers (ARBs) is commonly used to lower high blood pressure. This class includes drugs such as losartan (brand name: Cozaar), candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), telmisartan (Micardis) and valsartan (Diovan). We asked how much this class of drugs lowers blood pressure and whether ...

Protocol: Primary objective:To quantify the dose-related effects of various doses and types of calcium channel blockers on systolic and diastolic blood pressure versus placebo in patients with primary hypertension. Secondary objectives:1. To determine the effects of calcium channel blockers on variability of blood pressure.2. To determine the ...

Protocol: Primary objective: To quantify the additional reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP) of calcium-channel blocker (CCB) therapy as a second-line drug in hypertensive patients. Secondary objectives: 1. To determine the effects of second-line CCB on variability of blood pressure.2. To determine the ...

Protocol: Primary objective: To quantify the additional reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP) of drugs inhibiting the renin-angiotensin system (RAS) as a second-line drug in hypertensive patients. Secondary objectives: 1. To determine the effects of second-line RAS inhibitor on variability of blood pressure.2. ...

Protocol: The primary objective of this review is to assess the effectiveness of adding one platinum compound to other chemotherapy regimens in the first line treatment of metastatic colorectal cancer.