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Antibióticos para la prevención de la neumonía en niños con sarampiónShann F, D'Souza RM, D'Souza R
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Resumen en términos sencillosMeasles causes more than a million deaths a year, of which most are children under five years of age who die from pneumonia. The objective of this review was to assess the effects of antibiotics given to children with measles on reducing pneumonia or mortality, and to assess whether antibiotics should be given to all children with measles in communities with a high fatality rate.After an analysis of six trials which included 1304 children, the reviewers concluded that the evidence for giving antibiotics to all children with measles was very weak. Available evidence suggests that antibiotics should be given only if a child has clinical signs of pneumonia or other evidence of sepsis. Éste es el resumen de una revisión Cochrane traducida. La Colaboración Cochrane prepara y actualiza estas revisiones sistemáticas. El texto completo de la revisión traducida se publica en La Biblioteca Cochrane Plus (ISSN 1745-9990). De La Biblioteca Cochrane Plus, número 2, 2008. Oxford, Update Software Ltd. Todos los derechos están reservados.
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2008 ResumenAntecedentesMeasles causes more than a million deaths a year, of which most are children under five years of age who die from pneumonia. ObjectivosThe objective of this review was to assess the effects of antibiotics given to children with measles on reducing pneumonia or mortality, and to assess whether antibiotics should be given to all children with measles in communities with a high fatality rate. Estrategia de búsquedaWe searched MEDLINE (1966 - 1999), EMBASE (1980-1999) and the specialized trials register of the Acute Respiratory Infections Group in August 1999, and all relevant journals in the University of Melbourne medical library for the years 1935-46. Criterios de selecciónRandomised or controlled trials of antibiotics for children with measles. Recopilación y análisis de datosTwo reviewers independently extracted data and assessed trial quality. Resultados principalesSix trials with 1304 children were included. All but one of the trials were unblinded, and randomisation was either not described or was by alternate allocation. In four studies, the incidence of pneumonia in the control group was similar to that in the antibiotic prophylaxis group; in the other two studies, the incidence of pneumonia was unusually high in the control group so these children had a higher complication rate than the antibiotic group. Four of the 764 children given antibiotics died compared with one of the 637 controls. Conclusiones de los revisoresThe quality of the trials reviewed was poor, and they provide very weak evidence for giving antibiotics to all children with measles. Available evidence suggests that antibiotics should be given only if a child has clinical signs of pneumonia or other evidence of sepsis. |