Caffeine for cognition (protocol stage)

Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients (protocol stage)

Calcium antagonists for unstable angina (protocol stage)

Calcium channel blockers for primary Raynaud's Phenomenon (protocol stage)

Calcium channel blockers for Raynaud's phenomenon in patients with scleroderma (protocol stage)

Calcium channel blockers for treatment of irritable bowel syndrome (protocol stage)

Calcium channel blockers for ureteral stones (protocol stage)

Calcium channel blockers versus other classes of drugs for hypertension (protocol stage)

Calcium dialysate concentration for peritoneal dialysis (protocol stage)

Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes (protocol stage)

Cannabinoids for multiple sclerosis (protocol stage)

Carbamazepine and oxcarbazepine for the treatment of behavioural and psychological symptoms of dementia (BPSD) (protocol stage)

Carbohydrates for improving the cognitive performance of independent-living older adults with normal cognition or mild cognitive impairment (protocol stage)

Cardiotocography versus intermittent auscultation of fetal heart on admission to labour ward for assessment of fetal wellbeing (protocol stage)

Care delivery and self-management strategies for children with epilepsy (protocol stage)

Carnitine for fatigue in multiple sclerosis (protocol stage)

Case management: effects on professional practice and health care outcomes (protocol stage)

Catheter ablation for paroxysmal and persistent atrial fibrillation (protocol stage)

Catheter impregnation, coating or bonding for reducing central venous catheter related infections in adults (protocol stage)

Cefepime versus other beta-lactam antibiotics for the treatment of infections in non-neutropenic patients (protocol stage)

Celiac plexus block for pancreatic cancer pain in adults (protocol stage)

Cemented versus cementless in total knee arthroplasty for osteoarthrosis and other non-traumatic diseases (protocol stage)

Cemented versus cementless surgical approach for total hip arthroplasty revision (protocol stage)

Cemented versus cementless total hip arthroplasty for osteoarthrosis and other non-traumatic diseases (protocol stage)

Centralisation of services for gynaecological cancer (protocol stage)

Cerebrolysin for acute Ischaemic stroke (protocol stage)

Cerebrolysin for Alzheimer's disease (protocol stage)

Certolizumab pegol (CDP870) for rheumatoid arthritis in adults (protocol stage)

Cervical pessary for preventing preterm birth (protocol stage)

Cervical preparation for first trimester surgical abortion (protocol stage)

Cervical preparation for second trimester dilation and evacuation (protocol stage)

Cesarean section for the prevention of anal incontinence (protocol stage)

Changes in out-of-pocket payments on utilisation of health care services (protocol stage)

Checking reference lists to find additional studies for systematic reviews (protocol stage)

Chemo-mechanical treatment of tooth decay (protocol stage)

Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin Lymphoma (protocol stage)

Chemotherapy alone vs. radiotherapy alone vs. chemotherapy plus radiotherapy in the primary treatment of localised non-Hodgkin's lymphoma (protocol stage)

Chemotherapy and supportive care versus supportive care alone in advanced non-small cell lung cancer (protocol stage)

Chemotherapy and/or radiotherapy after surgery for ovarian carcinosarcoma (protocol stage)

Chemotherapy for brain metastases from small cell lung cancer (protocol stage)

Chemotherapy for children with medulloblastoma (protocol stage)

Chemotherapy for gallbladder cancer (protocol stage)

Chemotherapy for malignant germ cell ovarian cancer in patients with early stage, advanced and recurrent disease (protocol stage)

Chemotherapy for metastatic and recurrent cervical cancer (protocol stage)

Chemotherapy of second-stage Human African trypanosomiasis (protocol stage)

Chemotherapy with Camptothecin compounds for metastatic colorectal cancer (protocol stage)

Chemotherapy with platinum compounds for metastatic colorectal cancer (protocol stage)

Chemotherapy, surgery and radiotherapy for locally advanced breast cancer (protocol stage)

Chest pain observation units for patients with symptoms suggestive of acute cardiac ischaemia (protocol stage)

Chest physiotherapy for pneumonia in adults (protocol stage)

Chewing gum for postoperative ileus (protocol stage)

Child-focused cognitive behavioural therapy for children who have been physically abused (protocol stage)

Chinese herbal medicine for allergic rhinitis (protocol stage)

Chinese herbal medicine for diabetic peripheral neuropathy (protocol stage)

Chinese herbal medicine for female subfertility (protocol stage)

Chinese herbal medicine for subfertile women with polycystic ovarian syndrome (protocol stage)

Chinese herbal medicines alone or combined with vitamins for the treatment of gastric precancerous lesions (protocol stage)

Chinese herbal medicines for induction of remission in advanced or late gastric cancer (protocol stage)

Chinese herbal medicines for treating diabetic foot ulcers (protocol stage)

Chinese herbal medicines for weight loss (protocol stage)

Chinese herbs for insomnia (protocol stage)

Chinese medicinal herbs for diabetic kidney disease (protocol stage)

Chinese medicinal herbs for urinary calculi (protocol stage)

Chinese medicinal herbs for vaginal bleeding of medical abortion (protocol stage)

Chiropractic for infantile colic (protocol stage)

Chiropractic interventions (other than trials of spinal manipulation alone) for low-back pain (protocol stage)

Chlamydia antibody titer testing versus hysterosalpingography for detection of tubal pathology in subfertile women (protocol stage)

Chlorhexidine interventions for the prevention of caries in adults (protocol stage)

Chlorhexidine skin care for the prevention of infection in term neonates (protocol stage)

Chloroquines for the treatment of osteoarthritis (protocol stage)

Chlorpromazine for psychosis induced aggression or agitation (protocol stage)

Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease (protocol stage)

Chondroitin for osteoarthritis (protocol stage)

Chronic disease management programs for adults with asthma (protocol stage)

Chronotherapy versus conventional drug therapy for hypertension (protocol stage)

Chuanxiong preparations for preventing stroke (protocol stage)

Cilostazol versus aspirin for secondary prevention of vascular events after stroke (protocol stage)

Cinnamon for diabetes mellitus (protocol stage)

Circuit class therapy for improving mobility after stroke (protocol stage)

Cisapride for intestinal constipation (protocol stage)

Cisplatin plus etoposide versus other platin-based regimens for patients with extensive small cell lung cancer (protocol stage)

Citalopram versus other anti-depressive agents for depression (protocol stage)

Clinical assessment for diagnosing congenital heart disease in newborn infants with Down syndrome (protocol stage)

Clinical hypnosis for acute pain in adults (protocol stage)

Clinical pathways: effects on professional practice, patient outcomes, length of stay and hospital costs (protocol stage)

Clinically indicated replacement versus routine replacement of peripheral venous catheters (protocol stage)

Clobazam monotherapy for partial onset or generalized onset seizures (protocol stage)

Closure methods for laparotomy incisions (protocol stage)

Clozapine versus other atypical antipsychotics for schizophrenia (protocol stage)

Codeine, alone and with paracetamol (acetaminophen), for cancer pain (protocol stage)

Coenzyme Q10 for Parkinson's disease (protocol stage)

Cognition-based interventions for healthy older people and people with mild cognitive impairment (protocol stage)

Cognitive behaviour therapy versus specific pharmacological treatments for schizophrenia (protocol stage)

Cognitive behaviour therapy versus standard care for schizophrenia (protocol stage)

Cognitive Behavioural Therapy (CBT) for adults with HIV (protocol stage)

Cognitive behavioural therapy for anxiety disorders in later life (protocol stage)

Cognitive behavioural therapy for insomnia (protocol stage)

Cognitive behavourial therapy for patients with implantable cardioverter-defibrillators (protocol stage)

Cognitive reframing for carers of people with dementia (protocol stage)

Cognitive rehabilitation for occupational outcomes after traumatic brain injury (protocol stage)

Cognitive stimulation to improve cognitive functioning in people with dementia (protocol stage)

Cognitive-behavioural therapy for parents who have physically abused their children (protocol stage)

Collaboration between local health and local government agencies for health improvement (protocol stage)

Collaborative care for depression and anxiety problems in primary care (protocol stage)

Colloid versus crystalloid solutions for priming cardiopulmonary bypass circuits (protocol stage)

Colonoscopic polypectomy for prevention of colorectal cancer (protocol stage)

Colony stimulating factors for afebrile neutropenia in cancer patients (protocol stage)

Colony-stimulating factors for the prevention of chemotherapy induced febrile neutropenia in breast cancer patients (protocol stage)

Colorectal stents for the management of malignant colonic obstructions (protocol stage)

Combination inhaled steroid and long-acting beta-agonist versus tiotropium for chronic obstructive pulmonary disease (protocol stage)

Combination of tocolytic agents for inhibiting preterm labour (protocol stage)

Combinations of insulin and oral hypoglycaemic agents for people with type 2 diabetes mellitus on insulin treatment (protocol stage)

Combined inhaled beta-agonist and anticholinergic agents in the emergency management of adult asthmatic patients (protocol stage)

Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD) (protocol stage)

Combined spinal-epidural versus spinal anaesthesia for caesarean section (protocol stage)

Combined therapy with statins and fibrates for people with dyslipidaemia (protocol stage)

Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma (protocol stage)

Community based management of neonatal sepsis in developing countries (protocol stage)

Community clinics versus home management for leg ulcer treatment (protocol stage)

Community-based intervention package for preventing maternal morbidity and mortality and improving neonatal outcomes (protocol stage)

Comparing antibiotics for acute exacerbations of chronic obstructive pulmonary disease (protocol stage)

Comparison of chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for patients with early unfavourable or advanced stage Hodgkin lymphoma (protocol stage)

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding (protocol stage)

Comparison of intraocular lens types for cataract surgery in eyes with uveitis (protocol stage)

Comparison of medicinal herbs for chronic hepatitis B virus infection (protocol stage)

Complementary therapies for acne vulgaris (protocol stage)

Complete decongestive therapy for lymphedema following breast cancer treatment (protocol stage)

Complex interventions for preventing diabetic foot ulceration (protocol stage)

Comprehensive geriatric assessment for older adults admitted to hospital (protocol stage)

Comprehensive physiotherapy for rheumatoid arthritis (protocol stage)

Computer assisted knee arthroplasty for osteoarthritis and other non-traumatic diseases (protocol stage)

Computer assisted surgery for knee ligament reconstruction (protocol stage)

Computer-based interventions for weight loss or weight maintenance in overweight or obese people (protocol stage)

Computer-generated paper reminders: effects on professional practice and health care outcomes (protocol stage)

Conscious sedation for dental anxiety (protocol stage)

Conservative interventions for the management of foreign body impaction in the oesophagus (protocol stage)

Conservative management of nocturia in adults (protocol stage)

Consultation letters for medically unexplained physical symptoms (protocol stage)

Consultation liaison in primary practice for mental health problems (protocol stage)

Consumer-oriented interventions for evidence-based prescribing and medicine use: an overview of systematic reviews (protocol stage)

Continuation and maintenance treatments for depressive disorder in older adults (protocol stage)

Continuous glucose monitoring systems for type 1 diabetes mellitus (protocol stage)

Continuous interscalene blockade versus parenteral analgesia for postoperative pain relief after major shoulder surgery (protocol stage)

Continuous positive airway pressure for cardiovascular disease associated with sleep apneoa (protocol stage)

Continuous quality improvement: effects on professional practice and healthcare outcomes (protocol stage)

Continuous renal replacement modalities for acute kidney failure in critically ill patients (protocol stage)

Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus (protocol stage)

Contrast agents for preventing contrast-induced nephropathy (protocol stage)

Control interventions for preventing spread of vancomycin-resistant enterococci (VRE) in hospitals (protocol stage)

Controlled cord traction for the third stage of labour (protocol stage)

Cooling for cerebral protection during brain surgery (protocol stage)

Copper containing intra-uterine devices versus depot progestogens for contraception (protocol stage)

Corticosteroid injections for tennis elbow (protocol stage)

Corticosteroid regimens for treatment of acute and chronic graft versus host disease (GvHD) after allogenic stem cell transplantation (protocol stage)

Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy (protocol stage)

Corticosteroids for ocular toxoplasmosis (protocol stage)

Corticosteroids for pneumonia (protocol stage)

Corticosteroids for the common cold (protocol stage)

Covering ileo- or colostomy in anterior resection for rectal carcinoma (protocol stage)

Cox-2 Inhibitors in the Prevention of Melanoma (protocol stage)

Creatine for amyotrophic lateral sclerosis/motor neuron disease (protocol stage)

Cryoablation versus radiofrequency ablation for the treatment of small renal cell carcinoma (protocol stage)

Cryotherapy following total knee replacement (protocol stage)

Culture media for human preimplantation embryos for in assisted reproductive technology cycles (protocol stage)

Cultured epithelial autograft in the treatment of acute burn wounds (protocol stage)

Cyanoacrylate microbial sealants for skin preparation prior to surgery (protocol stage)

Cycled light in the intensive care unit for preterm/low birth weight infants (protocol stage)

Cyclo-oxygenase (COX) inhibitors for preventing preterm labour (protocol stage)

Cyclophosphamide for interstitial lung disease (protocol stage)

Cyclophosphamide versus ifosfamide for paediatric and young adult sarcoma patients (protocol stage)

Cyclosporine for maintenance of remission in Crohn's disease (protocol stage)

Cytosine arabinoside for the treatment of acute promyelocytic leukaemia (protocol stage)