5-FU for genital warts in non-immunocompromised individuals (protocol stage)

Absorbable versus non-absorbable sutures for primary closure of traumatic lacerations and surgical wounds (protocol stage)

Acamprosate for alcohol dependence (protocol stage)

Acetylcholinesterase inhibitors for schizophrenia (protocol stage)

Acetylsalicylic acid (Aspirin) for primary prevention of cardiovascular disease in type 2 diabetes mellitus (protocol stage)

Active cycle of breathing technique for cystic fibrosis (protocol stage)

Active versus expectant management for women in the third stage of labour (protocol stage)

Acupressure for motion sickness (protocol stage)

Acupuncture for acute management and rehabilitation of traumatic brain injury (protocol stage)

Acupuncture for attention-deficit hyperactivity disorder (ADHD) in children and adolescents (protocol stage)

Acupuncture for autistic spectrum disorder (protocol stage)

Acupuncture for benign prostatic hyperplasia (protocol stage)

Acupuncture for bladder dysfunction after spinal cord injury (protocol stage)

Acupuncture for cancer pain in adults (protocol stage)

Acupuncture for children with cerebral palsy (protocol stage)

Acupuncture for chronic constipation (protocol stage)

Acupuncture for chronic fatigue syndrome (protocol stage)

Acupuncture for chronic hepatitis B virus infection (protocol stage)

Acupuncture for Gilles de la Tourette's syndrome (protocol stage)

Acupuncture for Guillain-Barré syndrome (protocol stage)

Acupuncture for hypoxic ischemic encephalopathy in neonates (protocol stage)

Acupuncture for menopausal hot flushes (protocol stage)

Acupuncture for myopia in children and adolescents (protocol stage)

Acupuncture for pain in endometriosis (protocol stage)

Acupuncture for Parkinson's Disease (protocol stage)

Acupuncture for peripheral joint osteoarthritis (protocol stage)

Acupuncture for polycystic ovarian syndrome (protocol stage)

Acupuncture for postherpetic neuralgia (protocol stage)

Acupuncture for premenstrual syndrome (protocol stage)

Acupuncture for primary dysmenorrhoea (protocol stage)

Acupuncture for symptomatic treatment of diabetic peripheral neuropathy (protocol stage)

Acupuncture for the treatment of post-operative pain (protocol stage)

Acupuncture for tinnitus (protocol stage)

Acupuncture for treating fibromyalgia (protocol stage)

Acupuncture for treatment of erectile dysfunction (protocol stage)

Acupuncture for urinary incontinence in adults without neurological disease (protocol stage)

Acupuncture for uterine fibroids (protocol stage)

Adefovir dipivoxil for chronic hepatitis B (protocol stage)

Adenoidectomy for recurrent or chronic nasal symptoms and middle ear disease in children up to 18 years of age (protocol stage)

Adenosin-diphosphate (ADP) receptor antagonists (clopidogrel, ticlopidine) for the prevention of cardiovascular disease in type 2 diabetes mellitus (protocol stage)

Adherence compounds in embryo transfer media for assisted reproductive technologies (protocol stage)

Adjunctive antithyroid drugs in radioiodine therapy for hyperthyroidism (protocol stage)

Adjunctive hyperbaric oxygen for necrotizing fasciitis (protocol stage)

Adjunctive steroid therapy for managing tuberculosis (protocol stage)

Adjusted indirect comparison for estimating relative effects of competing healthcare interventions (protocol stage)

Adjusting the pH of lidocaine for reducing pain on injection (protocol stage)

Adjuvant chemotherapy and/or radiotherapy after surgery for uterine carcinosarcoma (protocol stage)

Adjuvant chemotherapy for endometrial cancer (protocol stage)

Adjuvant Gonadotropin-releasing hormone analogues for chemotherapy induced premature ovarian failure in premenopausal women (protocol stage)

Adjuvant radiotherapy following radical prostatectomy for prostate cancer (protocol stage)

Adrenaline and vasopressin for cardiac arrest (protocol stage)

Adrenocorticotropic hormone for acute gout (protocol stage)

Advanced glycation end product (AGE) inhibitors for preventing the progression of diabetic kidney disease (protocol stage)

Adverse cardiac effects of calcium channel blockers (protocol stage)

Adverse gastrointestinal effects of COX-2 Inhibitors for inflammatory diseases (protocol stage)

Advice to rest in bed versus advice to stay active for acute low-back pain and sciatica (protocol stage)

Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) (protocol stage)

Albumin and other plasma expanders for paracentesis treatment of ascites in cirrhotic patients (protocol stage)

Alemtuzumab for chronic lymphocytic leukaemia (protocol stage)

Alendronate for preventing tooth loss in postmenopausal women (protocol stage)

Alfuzosin for benign prostatic hyperplasia (protocol stage)

Allergen injection immunotherapy for perennial allergic rhinitis (protocol stage)

Allogeneic peripheral blood stem cells transplantation versus bone marrow transplantation for the therapy of hematological malignancies (protocol stage)

Allopurinol for chronic gout (protocol stage)

Almitrine-Raubasine combination for dementia (protocol stage)

Alpha-interferon for chronic hepatitis B (protocol stage)

Alpha-lipoic acid for diabetic peripheral neuropathy (protocol stage)

Alprazolam for depression (protocol stage)

Alterations in parenteral nutrition management for the treatment of parenteral nutrition-associated cholestasis in term and preterm infants (protocol stage)

Altered auditory feedback treatments for stuttering in childhood and adolescence (protocol stage)

Altered dietary salt intake for preventing and treating diabetic kidney disease (protocol stage)

Alternative magnesium sulphate regimens for women with pre-eclampsia and eclampsia (protocol stage)

Alternative methods of adenoidectomy versus curettage in children (protocol stage)

Alternative positions for the baby at birth before clamping the umbilical cord (protocol stage)

Alternative strategies for diagnosing gestational diabetes mellitus to improve maternal and infant health (protocol stage)

Alternative strategies for drainage of peritonsillar abscess (protocol stage)

Amfetamines for attention deficit / hyperactivity disorder in adults (protocol stage)

Amide local anaesthetics for post-operative pain relief following third molar surgery (protocol stage)

Amino acid, fat emulsion and energy supplementation for severe pneumonia in the elderly (protocol stage)

Aminobisphosphonates versus other active treatment for Paget's disease of the bone in adults (protocol stage)

Aminoglycosides and other nonsense suppression therapies for the treatment of dystrophinopathy (protocol stage)

Aminophylline for bradyasystolic cardiac arrest in adults (protocol stage)

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death (protocol stage)

Amisulpride versus other atypical antipsychotics for schizophrenia (protocol stage)

Amphotericin B deoxycholate versus liposomal amphotericin B: effects on kidney function (protocol stage)

Anaesthesia for cardioversion (protocol stage)

Anaesthetic interventions for prevention of awareness during surgery (protocol stage)

Anaesthetic techniques for open inguinal hernia repair in adults (protocol stage)

Analgesia for relief of pain due to uterine cramping/involution after birth. (protocol stage)

Analgesics for postoperative pain after tonsillectomy and adenoidectomy in children (protocol stage)

Analgo-sedation for diagnostic and therapeutic endoscopic or radiologic procedures in adults (protocol stage)

Androgens for the anaemia of chronic kidney disease in adults (protocol stage)

Angiogenesis-inhibitors for metastatic thyroid cancer (protocol stage)

Angiogenesis-inhibitors for the treatment of ovarian cancer (protocol stage)

Angiotensin converting enzyme inhibitor induced angioedema in patients with primary hypertension (protocol stage)

Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers for dialysis patients (protocol stage)

Angiotensin converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1-3) non-diabetic chronic kidney disease (protocol stage)

Angiotensin converting enzyme inhibitors for heart failure (protocol stage)

Angiotensin receptor blockers for heart failure (protocol stage)

Antacids and lifestyle advice for reflux oesophagitis and Endoscopy Negative Reflux Disease (protocol stage)

Antenatal breastfeeding education for increasing breastfeeding duration (protocol stage)

Antenatal cardiotocography for fetal assessment (protocol stage)

Antenatal screening for Down's syndrome - generic protocol (protocol stage)

Anterior repositioning splint for temporomandibular joint disc displacement (protocol stage)

Anthelmintics for people with neurocysticercosis (protocol stage)

Anti Spastic Medication for Spasticity in Cerebral Palsy (protocol stage)

Anti-angiogenic therapy for lung cancer (protocol stage)

Anti-depressants and centrally active agents for fibromyalgia syndrome (protocol stage)

Anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease (protocol stage)

Anti-inflammatory agents for preventing the progression of cervical intraepithelial neoplasia (protocol stage)

Anti-inflammatory medications for obstructive sleep apnea in children (protocol stage)

Anti-pseudomonal beta-lactam monotherapy for the initial, empirical, treatment of febrile neutropenia: comparison of beta-lactams (protocol stage)

Anti-TNF-α treatment for pelvic pain associated with endometriosis (protocol stage)

Anti-vascular endothelial growth factor for macular edema secondary to central retinal vein occlusion (protocol stage)

Anti-vascular endothelial growth factor for neovascular glaucoma (protocol stage)

Antiandrogenic treatment for sexual disinhibition in male patients with dementia (protocol stage)

Antibiotic prophylaxis for elective hysterectomy (protocol stage)

Antibiotic prophylaxis for medical and surgical first-trimester induced abortion (protocol stage)

Antibiotic prophylaxis for patients undergoing elective endoscopic retrograde cholangiopancreatography (protocol stage)

Antibiotic prophylaxis for patients undergoing elective laparoscopic cholecystectomy (protocol stage)

Antibiotic prophylaxis for transrectal prostate biopsy (protocol stage)

Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section (protocol stage)

Antibiotic regimens for the empirical treatment of newborn infants with necrotizing enterocolitis (protocol stage)

Antibiotic regimes and dosages for appendectomy (protocol stage)

Antibiotics and antivirals for dementia and mild cognitive impairment (protocol stage)

Antibiotics for asymptomatic urinary tract infection in the elderly (protocol stage)

Antibiotics for cholangitis and/or cholecystitis (protocol stage)

Antibiotics for clinically diagnosed acute rhinosinusitis in adults (protocol stage)

Antibiotics for hepatic encephalopathy (protocol stage)

Antibiotics for induction of remission in Crohn's disease (protocol stage)

Antibiotics for induction of remission in ulcerative colitis (protocol stage)

Antibiotics for meconium-stained amniotic fluid in labour for preventing neonatal sepsis (protocol stage)

Antibiotics for neonates born through meconium stained amniotic fluid (protocol stage)

Antibiotics for preventing hypertensive diseases in pregnancy (protocol stage)

Antibiotics for preventing urinary tract infections in kidney transplant recipients (protocol stage)

Antibiotics for reactive arthritis (protocol stage)

Antibiotics for secondary prevention of coronary heart disease (protocol stage)

Antibiotics for Staphylococcus aureus pneumonia in adults (protocol stage)

Antibiotics for the management of constipation predominant irritable bowel syndrome and chronic constipation (protocol stage)

Antibiotics for treating human brucellosis (protocol stage)

Antibiotics for treating non typhoidal Salmonella diarrhoea (protocol stage)

Antibiotics for treating postoperative endophthalmitis after cataract surgery (protocol stage)

Antibiotics for treating uncomplicated urinary tract infection in children (protocol stage)

Antibiotics for undifferentiated acute respiratory tract infections in children under five years of age (protocol stage)

Antibiotics for ventilator-associated pneumonia (protocol stage)

Antibiotics plus colony stimulating factors (CSFs) versus CSFs alone and antibiotics plus CSFs versus no prophylaxis for the prevention of infections in cancer patients receiving myelosuppressive chemotherapy or haematopoetic stem cell transplantation (protocol stage)

Antibiotics plus colony stimulating factors versus antibiotics alone for the prevention of infections in cancer patients receiving myelosuppressive chemotherapy or haematopoetic stem cell transplantation (protocol stage)

Antibiotics to prevent complications following tooth extractions (protocol stage)

Antibody immunosuppression for pancreas and kidney/pancreas transplant recipients (protocol stage)

Anticholinergic therapy for acute asthma in children (protocol stage)

Anticholinesterase treatment for myasthenia gravis (protocol stage)

Anticoagulant therapy for deep vein thrombosis (DVT) in pregnancy (protocol stage)

Anticoagulants (extended duration) for prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair (protocol stage)

Anticonvulsants for restless legs syndrome (protocol stage)

Anticonvulsants for tinnitus (protocol stage)

Antidepressants for central pain (protocol stage)

Antidepressants for depression in physically ill people (protocol stage)

Antidepressants for the treatment of abdominal pain-related functional gastrointestinal disorders in children and adolescents (protocol stage)

Antiemetic medication for prevention and treatment of chemotherapy induced nausea and vomiting in childhood (protocol stage)

Antiepileptic drugs as prophylaxis for postcraniotomy seizures (protocol stage)

Antiepileptic drugs for the primary and secondary prevention of seizures after stroke (protocol stage)

Antiepileptic drugs versus no treatment or placebo for children with benign epilepsy with centro temporal spikes (protocol stage)

Antiepileptics for aggression and associated impulsivity (protocol stage)

Antifungal agents for the treatment of mucocutaneous candidiasis in neonates and children (protocol stage)

Antifungal therapy in infants and children with proven, probable or suspected invasive fungal infections (protocol stage)

Antigen-specific active immunotherapy for ovarian cancer (protocol stage)

Antiglucocorticoid and related treatments for psychosis (protocol stage)

Antihistamines as an adjunct to topical nasal steroids for intermittent and persistent allergic rhinitis in children (protocol stage)

Antihistamines for motion sickness (protocol stage)

Antihypertensive agents for preventing the progression of diabetic kidney disease (protocol stage)

Antihypertensive drugs for mild hypertension (protocol stage)

Antimicrobial agents for treating uncomplicated urinary tract infection in women (protocol stage)

Antioxidant micronutrients for lung disease in cystic fibrosis (protocol stage)

Antioxidant supplements for liver diseases (protocol stage)

Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract (protocol stage)

Antioxidants for chronic kidney disease (protocol stage)

Antioxidants for female subfertility (protocol stage)

Antioxidants for male subfertility (protocol stage)

Antiplatelet agents for intermittent claudication (protocol stage)

Antipsychotic drugs for anorexia nervosa (protocol stage)

Antipsychotic medication for early episode schizophrenia (protocol stage)

Antipsychotic switching for people with schizophrenia who have neuroleptic-induced weight or metabolic problems (protocol stage)

Antiretroviral resistance testing in treatment-naive HIV-infected adults (protocol stage)

Antiretroviral therapy for infants with HIV infection (protocol stage)

Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction (protocol stage)

Antiviral agents for prophylaxis of herpesviridae infections in patients with haematological malignancies (protocol stage)

Antiviral agents for treating CMV infection of the nervous system in people with HIV (protocol stage)

Antiviral prophylactic intervention for hepatitis C virus in patients undergoing liver transplantation (protocol stage)

Antiviral prophylaxis for varicella zoster in immunocompromised patients (excluding haematological malignancies) (protocol stage)

Antiviral therapy for symptomatic congenital cytomegalovirus infection in neonates and infants up to 3 months of age (protocol stage)

Antiviral treatment for chronic hepatitis C in patients with human immunodeficiency virus (protocol stage)

Antiviral treatments for lamivudine-resistant chronic hepatitis B adult patients (protocol stage)

Antivirals for idiopathic sudden sensorineural hearing loss (protocol stage)

Appendix stump closure during laparoscopic appendectomy (protocol stage)

Aquatic therapy exercise for treating rheumatoid arthritis (protocol stage)

Aripiprazole alone or in combination for acute mania (protocol stage)

Aripiprazole for psychosis-induced aggression or agitation (protocol stage)

Aripiprazole versus placebo for schizophrenia (protocol stage)

Aromatase inhibitors for ovulation induction (protocol stage)

Aromatherapy for treatment of postoperative nausea and vomiting (protocol stage)

Arterial ligation versus embolisation for intractable posterior epistaxis (protocol stage)

Arthroscopic lavage for osteoarthritis of the knee (protocol stage)

Arthroscopy for temporomandibular disorders (protocol stage)

As required versus fixed schedule analgesic administration schedules for treating postoperative pain in children and adults (protocol stage)

Aspirin desensitisation therapy for aspirin-intolerant chronic rhinosinusitis (protocol stage)

Aspirin for primary prevention of coronary heart disease (protocol stage)

Aspirin with or without an antiemetic for acute migraine in adults (protocol stage)

Aspirin, steroidal and non-steroidal anti-inflammatory drugs for Alzheimer's disease (protocol stage)

Atherectomy for peripheral arterial disease (protocol stage)

Atomoxetine for attention deficit hyperactivity disorder in people with intellectual disabilities (protocol stage)

Atraumatic restorative treatment versus conventional restorative treatment for the management of dental caries (protocol stage)

Atypical Antipsychotics for Tourette's Syndrome (protocol stage)

Augmentation of psychotherapy with d-cycloserine for anxiety disorders (protocol stage)

Auricular acupuncture for opiate dependence in substance misuse treatment programmes (protocol stage)

Autologous platelet rich-plasma for treating chronic wounds (protocol stage)

Autologous stem cell transplantation vs chemotherapy in adult acute lymphocytic leukaemia (protocol stage)

Autologous versus prosthetic arteriovenous fistulae for vascular access (protocol stage)

Axillary staging for operable primary breast cancer. (protocol stage)

Azithromycin for treating uncomplicated malaria (protocol stage)

Azithromycin versus penicillin G Benzathine for early syphilis (protocol stage)

Azoles and ivermectin for treating strongyloides infection (protocol stage)

Bacille Calmette-Guerin (BCG) vaccine for induction of remission in Crohn's disease (protocol stage)

Balance training (proprioceptive training) for patients with rheumatoid arthritis. (protocol stage)

Band ligation versus beta-blockers for primary prevention of bleeding oesophageal varices (protocol stage)

Banding ligation versus beta-blockers for primary prophylaxis in oesophageal varices (protocol stage)

Banked preterm versus banked term human milk to promote growth and development in very low birth weight infants (protocol stage)

Bariatric surgery for non-alcoholic steatohepatitis in obese patients (protocol stage)

Behavioral interventions for increasing the use of condoms in women with HIV (protocol stage)

Behavioral interventions for reducing HIV infection in employees in occupational settings (protocol stage)

Behavioral interventions to reduce the transmission of HIV infection among commercial sex workers and their clients in developed countries (protocol stage)

Behavioral interventions to reduce the transmission of HIV infection among commercial sex workers and their clients in developing countries (protocol stage)

Behavioral therapies for migraine (protocol stage)

Behavioural interventions for children under five years with sleep difficulties (protocol stage)

Benzodiazepines for restless legs syndrome (protocol stage)

Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults (protocol stage)

Beta blockers for essential tremor (protocol stage)

Beta blockers for preventing stroke recurrence (protocol stage)

Beta blockers for stable angina (protocol stage)

Beta-2 agonists for exercise induced asthma (protocol stage)

Beta-adrenergic blockers for perioperative cardiac risk reduction in patients undergoing vascular surgery (protocol stage)

Beta-blocker plus nitrates for secondary prevention of variceal bleeding (protocol stage)

Beta-blockers alone or with endoscopic therapy for prevention of variceal rebleeding in portal hypertension (protocol stage)

Beta-blockers for heart failure (protocol stage)

Beta-blockers for mitral stenosis (protocol stage)

Beta-blockers for myocardial infarction (protocol stage)

Beta-blockers for unstable angina (protocol stage)

Bibliotherapy for sexual dysfunction (protocol stage)

Bicarbonate versus lactate solutions for acute haemodialysis (protocol stage)

Bicarbonate versus lactate solutions for acute peritoneal dialysis (protocol stage)

Bilateral versus single internal mammary artery bypass grafts for coronary arterial atherosclerosis (protocol stage)

Biocompatible dialysis fluids for peritoneal dialysis (protocol stage)

Biodegradable anastomotic ring for gastrointestinal anastomosis (protocol stage)

Biofeedback for pain during labour (protocol stage)

Biologics for chronic plaque psoriasis (protocol stage)

Biphasic versus monophasic waveforms for transthoracic defibrillation in out-of-hospital cardiac arrest (protocol stage)

Bisphosphonates for prevention of bone loss in women with early breast cancer (protocol stage)

Bisphosphonates in early prostate cancer (protocol stage)

Black cohosh (Cimicifuga spp.) for menopausal symptoms (protocol stage)

Blinded versus unblinded assessments of risk-of-bias in studies included in a systematic review (protocol stage)

Blood pressure control for diabetic retinopathy (protocol stage)

Blood pressure increasing effect of sibutramine in obese patients (protocol stage)

Blood pressure lowering efficacy of beta-1 selective beta blockers for primary hypertension (protocol stage)

Blood pressure lowering efficacy of beta-blockers as second-line therapy for primary hypertension (protocol stage)

Blood pressure lowering efficacy of calcium channel blockers for primary hypertension (protocol stage)

Blood pressure lowering efficacy of calcium-channel blockers as second-line therapy for primary hypertension (protocol stage)

Blood pressure lowering efficacy of drugs inhibiting the renin-angiotensin system as second-line therapy for primary hypertension (protocol stage)

Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension (protocol stage)

Blood pressure lowering efficacy of non-selective beta blockers for primary hypertension (protocol stage)

Blood pressure lowering efficacy of partial agonist beta blockers for primary hypertension (protocol stage)

Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension (protocol stage)

Blood pressure lowering efficacy of thiazide diuretics for primary hypertension (protocol stage)

Blood substitutes for avoiding allogeneic blood transfusion (protocol stage)

Blood transfusions for treating acute chest syndrome in people with sickle cell disease (protocol stage)

Blood-pressure-lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attacks (protocol stage)

Body position for spontaneously breathing preterm infants with apnoea (protocol stage)

Bone morphogenetic protein (BMP) for fracture healing in adults (protocol stage)

Boosted protease inhibitor (PI) monotherapy for treating HIV/AIDS (protocol stage)

Botulinum A toxin for focal hand dystonia (protocol stage)

Botulinum toxin A for the prevention of hip dislocation in cerebral palsy (protocol stage)

Botulinum toxin for adult spasticity after stroke or non-progressive brain lesion (protocol stage)

Botulinum toxin for myofascial pain syndromes in adults (protocol stage)

Botulinum toxin for the treatment of chronic idiopathic constipation (protocol stage)

Botulinum toxin type A and casting versus botulinum toxin type A or casting in treating equinus gait of children with cerebral palsy (protocol stage)

Botulinum toxin type A formulations in focal dystonias (protocol stage)

Bowel preparation for colonoscopy (protocol stage)

Braces for idiopathic scoliosis in adolescents (protocol stage)

Buprenorphine for cancer pain (protocol stage)

Bupropion for depression (protocol stage)

Caffeine for cognition (protocol stage)

Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients (protocol stage)

Calcium antagonists for unstable angina (protocol stage)

Calcium channel blockers for primary Raynaud's Phenomenon (protocol stage)

Calcium channel blockers for Raynaud's phenomenon in patients with scleroderma (protocol stage)

Calcium channel blockers for treatment of irritable bowel syndrome (protocol stage)

Calcium channel blockers for ureteral stones (protocol stage)

Calcium channel blockers versus other classes of drugs for hypertension (protocol stage)

Calcium dialysate concentration for peritoneal dialysis (protocol stage)

Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes (protocol stage)

Cannabinoids for multiple sclerosis (protocol stage)

Carbamazepine and oxcarbazepine for the treatment of behavioural and psychological symptoms of dementia (BPSD) (protocol stage)

Carbohydrates for improving the cognitive performance of independent-living older adults with normal cognition or mild cognitive impairment (protocol stage)

Cardiotocography versus intermittent auscultation of fetal heart on admission to labour ward for assessment of fetal wellbeing (protocol stage)

Care delivery and self-management strategies for children with epilepsy (protocol stage)

Carnitine for fatigue in multiple sclerosis (protocol stage)

Case management: effects on professional practice and health care outcomes (protocol stage)

Catheter ablation for paroxysmal and persistent atrial fibrillation (protocol stage)

Catheter impregnation, coating or bonding for reducing central venous catheter related infections in adults (protocol stage)

Cefepime versus other beta-lactam antibiotics for the treatment of infections in non-neutropenic patients (protocol stage)

Celiac plexus block for pancreatic cancer pain in adults (protocol stage)

Cemented versus cementless in total knee arthroplasty for osteoarthrosis and other non-traumatic diseases (protocol stage)

Cemented versus cementless surgical approach for total hip arthroplasty revision (protocol stage)

Cemented versus cementless total hip arthroplasty for osteoarthrosis and other non-traumatic diseases (protocol stage)

Centralisation of services for gynaecological cancer (protocol stage)

Cerebrolysin for acute Ischaemic stroke (protocol stage)

Cerebrolysin for Alzheimer's disease (protocol stage)

Certolizumab pegol (CDP870) for rheumatoid arthritis in adults (protocol stage)

Cervical pessary for preventing preterm birth (protocol stage)

Cervical preparation for first trimester surgical abortion (protocol stage)

Cervical preparation for second trimester dilation and evacuation (protocol stage)

Cesarean section for the prevention of anal incontinence (protocol stage)

Changes in out-of-pocket payments on utilisation of health care services (protocol stage)

Checking reference lists to find additional studies for systematic reviews (protocol stage)

Chemo-mechanical treatment of tooth decay (protocol stage)

Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin Lymphoma (protocol stage)

Chemotherapy alone vs. radiotherapy alone vs. chemotherapy plus radiotherapy in the primary treatment of localised non-Hodgkin's lymphoma (protocol stage)

Chemotherapy and supportive care versus supportive care alone in advanced non-small cell lung cancer (protocol stage)

Chemotherapy and/or radiotherapy after surgery for ovarian carcinosarcoma (protocol stage)

Chemotherapy for brain metastases from small cell lung cancer (protocol stage)

Chemotherapy for children with medulloblastoma (protocol stage)

Chemotherapy for gallbladder cancer (protocol stage)

Chemotherapy for malignant germ cell ovarian cancer in patients with early stage, advanced and recurrent disease (protocol stage)

Chemotherapy for metastatic and recurrent cervical cancer (protocol stage)

Chemotherapy of second-stage Human African trypanosomiasis (protocol stage)

Chemotherapy with Camptothecin compounds for metastatic colorectal cancer (protocol stage)

Chemotherapy with platinum compounds for metastatic colorectal cancer (protocol stage)

Chemotherapy, surgery and radiotherapy for locally advanced breast cancer (protocol stage)

Chest pain observation units for patients with symptoms suggestive of acute cardiac ischaemia (protocol stage)

Chest physiotherapy for pneumonia in adults (protocol stage)

Chewing gum for postoperative ileus (protocol stage)

Child-focused cognitive behavioural therapy for children who have been physically abused (protocol stage)

Chinese herbal medicine for allergic rhinitis (protocol stage)

Chinese herbal medicine for diabetic peripheral neuropathy (protocol stage)

Chinese herbal medicine for female subfertility (protocol stage)

Chinese herbal medicine for subfertile women with polycystic ovarian syndrome (protocol stage)

Chinese herbal medicines alone or combined with vitamins for the treatment of gastric precancerous lesions (protocol stage)

Chinese herbal medicines for induction of remission in advanced or late gastric cancer (protocol stage)

Chinese herbal medicines for treating diabetic foot ulcers (protocol stage)

Chinese herbal medicines for weight loss (protocol stage)

Chinese herbs for insomnia (protocol stage)

Chinese medicinal herbs for diabetic kidney disease (protocol stage)

Chinese medicinal herbs for urinary calculi (protocol stage)

Chinese medicinal herbs for vaginal bleeding of medical abortion (protocol stage)

Chiropractic for infantile colic (protocol stage)

Chiropractic interventions (other than trials of spinal manipulation alone) for low-back pain (protocol stage)

Chlamydia antibody titer testing versus hysterosalpingography for detection of tubal pathology in subfertile women (protocol stage)

Chlorhexidine interventions for the prevention of caries in adults (protocol stage)

Chlorhexidine skin care for the prevention of infection in term neonates (protocol stage)

Chloroquines for the treatment of osteoarthritis (protocol stage)

Chlorpromazine for psychosis induced aggression or agitation (protocol stage)

Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease (protocol stage)

Chondroitin for osteoarthritis (protocol stage)

Chronic disease management programs for adults with asthma (protocol stage)

Chronotherapy versus conventional drug therapy for hypertension (protocol stage)

Chuanxiong preparations for preventing stroke (protocol stage)

Cilostazol versus aspirin for secondary prevention of vascular events after stroke (protocol stage)

Cinnamon for diabetes mellitus (protocol stage)

Circuit class therapy for improving mobility after stroke (protocol stage)

Cisapride for intestinal constipation (protocol stage)

Cisplatin plus etoposide versus other platin-based regimens for patients with extensive small cell lung cancer (protocol stage)

Citalopram versus other anti-depressive agents for depression (protocol stage)

Clinical assessment for diagnosing congenital heart disease in newborn infants with Down syndrome (protocol stage)

Clinical hypnosis for acute pain in adults (protocol stage)

Clinical pathways: effects on professional practice, patient outcomes, length of stay and hospital costs (protocol stage)

Clinically indicated replacement versus routine replacement of peripheral venous catheters (protocol stage)

Clobazam monotherapy for partial onset or generalized onset seizures (protocol stage)

Closure methods for laparotomy incisions (protocol stage)

Clozapine versus other atypical antipsychotics for schizophrenia (protocol stage)

Codeine, alone and with paracetamol (acetaminophen), for cancer pain (protocol stage)

Coenzyme Q10 for Parkinson's disease (protocol stage)

Cognition-based interventions for healthy older people and people with mild cognitive impairment (protocol stage)

Cognitive behaviour therapy versus specific pharmacological treatments for schizophrenia (protocol stage)

Cognitive behaviour therapy versus standard care for schizophrenia (protocol stage)

Cognitive Behavioural Therapy (CBT) for adults with HIV (protocol stage)

Cognitive behavioural therapy for anxiety disorders in later life (protocol stage)

Cognitive behavioural therapy for insomnia (protocol stage)

Cognitive behavourial therapy for patients with implantable cardioverter-defibrillators (protocol stage)

Cognitive reframing for carers of people with dementia (protocol stage)

Cognitive rehabilitation for occupational outcomes after traumatic brain injury (protocol stage)

Cognitive stimulation to improve cognitive functioning in people with dementia (protocol stage)

Cognitive-behavioural therapy for parents who have physically abused their children (protocol stage)

Collaboration between local health and local government agencies for health improvement (protocol stage)

Collaborative care for depression and anxiety problems in primary care (protocol stage)

Colloid versus crystalloid solutions for priming cardiopulmonary bypass circuits (protocol stage)

Colonoscopic polypectomy for prevention of colorectal cancer (protocol stage)

Colony stimulating factors for afebrile neutropenia in cancer patients (protocol stage)

Colony-stimulating factors for the prevention of chemotherapy induced febrile neutropenia in breast cancer patients (protocol stage)

Colorectal stents for the management of malignant colonic obstructions (protocol stage)

Combination inhaled steroid and long-acting beta-agonist versus tiotropium for chronic obstructive pulmonary disease (protocol stage)

Combination of tocolytic agents for inhibiting preterm labour (protocol stage)

Combinations of insulin and oral hypoglycaemic agents for people with type 2 diabetes mellitus on insulin treatment (protocol stage)

Combined inhaled beta-agonist and anticholinergic agents in the emergency management of adult asthmatic patients (protocol stage)

Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD) (protocol stage)

Combined spinal-epidural versus spinal anaesthesia for caesarean section (protocol stage)

Combined therapy with statins and fibrates for people with dyslipidaemia (protocol stage)

Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma (protocol stage)

Community based management of neonatal sepsis in developing countries (protocol stage)

Community clinics versus home management for leg ulcer treatment (protocol stage)

Community-based intervention package for preventing maternal morbidity and mortality and improving neonatal outcomes (protocol stage)

Comparing antibiotics for acute exacerbations of chronic obstructive pulmonary disease (protocol stage)

Comparison of chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for patients with early unfavourable or advanced stage Hodgkin lymphoma (protocol stage)

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding (protocol stage)

Comparison of intraocular lens types for cataract surgery in eyes with uveitis (protocol stage)

Comparison of medicinal herbs for chronic hepatitis B virus infection (protocol stage)

Complementary therapies for acne vulgaris (protocol stage)

Complete decongestive therapy for lymphedema following breast cancer treatment (protocol stage)

Complex interventions for preventing diabetic foot ulceration (protocol stage)

Comprehensive geriatric assessment for older adults admitted to hospital (protocol stage)

Comprehensive physiotherapy for rheumatoid arthritis (protocol stage)

Computer assisted knee arthroplasty for osteoarthritis and other non-traumatic diseases (protocol stage)

Computer assisted surgery for knee ligament reconstruction (protocol stage)

Computer-based interventions for weight loss or weight maintenance in overweight or obese people (protocol stage)

Computer-generated paper reminders: effects on professional practice and health care outcomes (protocol stage)

Conscious sedation for dental anxiety (protocol stage)

Conservative interventions for the management of foreign body impaction in the oesophagus (protocol stage)

Conservative management of nocturia in adults (protocol stage)

Consultation letters for medically unexplained physical symptoms (protocol stage)

Consultation liaison in primary practice for mental health problems (protocol stage)

Consumer-oriented interventions for evidence-based prescribing and medicine use: an overview of systematic reviews (protocol stage)

Continuation and maintenance treatments for depressive disorder in older adults (protocol stage)

Continuous glucose monitoring systems for type 1 diabetes mellitus (protocol stage)

Continuous interscalene blockade versus parenteral analgesia for postoperative pain relief after major shoulder surgery (protocol stage)

Continuous positive airway pressure for cardiovascular disease associated with sleep apneoa (protocol stage)

Continuous quality improvement: effects on professional practice and healthcare outcomes (protocol stage)

Continuous renal replacement modalities for acute kidney failure in critically ill patients (protocol stage)

Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus (protocol stage)

Contrast agents for preventing contrast-induced nephropathy (protocol stage)

Control interventions for preventing spread of vancomycin-resistant enterococci (VRE) in hospitals (protocol stage)

Controlled cord traction for the third stage of labour (protocol stage)

Cooling for cerebral protection during brain surgery (protocol stage)

Copper containing intra-uterine devices versus depot progestogens for contraception (protocol stage)

Corticosteroid injections for tennis elbow (protocol stage)

Corticosteroid regimens for treatment of acute and chronic graft versus host disease (GvHD) after allogenic stem cell transplantation (protocol stage)

Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy (protocol stage)

Corticosteroids for ocular toxoplasmosis (protocol stage)

Corticosteroids for pneumonia (protocol stage)

Corticosteroids for the common cold (protocol stage)

Covering ileo- or colostomy in anterior resection for rectal carcinoma (protocol stage)

Cox-2 Inhibitors in the Prevention of Melanoma (protocol stage)

Creatine for amyotrophic lateral sclerosis/motor neuron disease (protocol stage)

Cryoablation versus radiofrequency ablation for the treatment of small renal cell carcinoma (protocol stage)

Cryotherapy following total knee replacement (protocol stage)

Culture media for human preimplantation embryos for in assisted reproductive technology cycles (protocol stage)

Cultured epithelial autograft in the treatment of acute burn wounds (protocol stage)

Cyanoacrylate microbial sealants for skin preparation prior to surgery (protocol stage)

Cycled light in the intensive care unit for preterm/low birth weight infants (protocol stage)

Cyclo-oxygenase (COX) inhibitors for preventing preterm labour (protocol stage)

Cyclophosphamide for interstitial lung disease (protocol stage)

Cyclophosphamide versus ifosfamide for paediatric and young adult sarcoma patients (protocol stage)

Cyclosporine for maintenance of remission in Crohn's disease (protocol stage)

Cytosine arabinoside for the treatment of acute promyelocytic leukaemia (protocol stage)

Daclizumab for relapsing remitting multiple sclerosis (protocol stage)

Damage control surgery for abdominal trauma (protocol stage)

Dance movement therapy for improving psychological and physical outcomes in cancer patients (protocol stage)

De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock (protocol stage)

Debriefing for the prevention of psychological trauma in women following childbirth (protocol stage)

Decongestants, antihistamines and nasal irrigation for acute sinusitis in children (protocol stage)

Deep brain stimulation of subthalamic nucleus for Parkinson's disease (protocol stage)

Deferasirox for managing iron overload in patients with myelodysplastic syndrome (protocol stage)

Deferasirox for managing iron overload in people with thalassaemia (protocol stage)

Deferasirox for managing transfusional iron overload in people with sickle cell disease (protocol stage)

Dehydroepiandrosterone for postmenopausal women (protocol stage)

Deliberate hypotension with propofol under anaesthesia for functional endoscopic sinus surgery (FESS) (protocol stage)

Dietary interventions for preventing complications in idiopathic hypercalciuria (protocol stage)

Dietary probiotic supplementation for allergic rhinitis (protocol stage)

Dietary supplements for established atopic eczema (protocol stage)

Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy (protocol stage)

Different antibiotic treatments for group A streptococcal pharyngitis (protocol stage)

Different communication strategies for disclosing results of diagnostic prenatal testing (protocol stage)

Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease (protocol stage)

Different insulin regimens for type 2 diabetes mellitus (protocol stage)

Different methods for the induction of labour in outpatient settings (protocol stage)

Different techniques of blood glucose monitoring in women with gestational diabetes for improving maternal and infant health (protocol stage)

Dilute versus full strength formula in preterm or very low birth weight infants (protocol stage)

Direct composite resin fillings versus amalgam fillings for permanent or adult posterior teeth (protocol stage)

Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous thromboembolism following total hip or knee replacement (protocol stage)

Disulfiram for the treatment of cocaine dependence (protocol stage)

Disulphiram for alcohol dependence (protocol stage)

DNA-repair pathway inhibitors for the treatment of ovarian cancer (protocol stage)

Donor organ preservation techniques for kidney transplantation (protocol stage)

Dopamine agonists for restless legs syndrome (protocol stage)

Doppler ultrasound, CT angiography, MR angiography, and contrast-enhanced MR angiography versus intra-arterial angiography for moderate and severe carotid stenosis in symptomatic patients (protocol stage)

Doxazosin for benign prostatic obstruction (protocol stage)

Dressings and topical agents containing hyaluronic acid for wound healing (protocol stage)

Dressings and topical agents for donor sites of split-thickness skin grafts (protocol stage)

Dressings and topical agents for preventing pressure sores (protocol stage)

Dressings for pressure sores (protocol stage)

Dressings for the treatment of diabetic foot ulceration (protocol stage)

Droperidol for treatment of nausea and vomiting in palliative care patients (protocol stage)

Drug interventions for pain relief during orthodontic treatment (protocol stage)

Drug interventions for the treatment of lipodystrophy in patients with HIV infection (protocol stage)

Drug therapy for preventing post-dural puncture headache (protocol stage)

Drug therapy for treating post-dural puncture headache (protocol stage)

Drug-eluting stents versus bare metal stents for angina or acute coronary syndromes: a systematic review (protocol stage)

Drugs and pacemakers for neurally mediated reflex syncope (protocol stage)

Drugs for nocturia in adults (protocol stage)

Drugs for perineal pain in the early postpartum period: generic protocol (protocol stage)

Drugs for the prevention and treatment of pruritus in patients receiving neuraxial opioids (protocol stage)

Drugs for the treatment of fatigue in palliative care (protocol stage)

Drugs for treating acute migraine headaches in children and adolescents (protocol stage)

Drugs for treating giardiasis (protocol stage)

Drugs for treatment of urinary retention after surgery in adults (protocol stage)

Duloxetine versus other anti-depressive agents for depression (protocol stage)

Duration of adjuvant chemotherapy for patients with non-metastatic colorectal cancer (protocol stage)

Duration of chemotherapy for metastatic breast cancer (protocol stage)

Duration of therapy for tuberculosis in patients infected with Human Immunodeficiency Virus (protocol stage)

Early additional food and fluids for healthy breastfed full-term infants (protocol stage)

Early combination therapy with levodopa and dopamine agonist for preventing motor fluctuations in Parkinson's disease (protocol stage)

Early laparoscopy versus clinical observation for the management of nonspecific acute abdominal pain in women of childbearing age (protocol stage)

Early laparoscopy versus observation for patients with acute abdominal pain (protocol stage)

Early mobilisation for elbow fractures in adults (protocol stage)

Early postoperative enteral nutrition versus parenteral nutrition for patients undergoing resection of stomach malignancy (protocol stage)

Early referral to specialist nephrology services for preventing the progression to end-stage kidney disease (protocol stage)

Early versus delayed refeeding for children with acute diarrhoea (protocol stage)

Early versus late initiation of epidural analgesia for labour (protocol stage)

Early versus late pre-intensive care unit admission broad spectrum antibiotics for severe sepsis in adults (protocol stage)

Early versus late removal of laryngeal mask airway (LMA) for general anaesthesia (protocol stage)

Early versus late tracheostomy for critically ill patients (protocol stage)

Early versus later discharge of physiologically stable preterm infants who are fully orally feeding (protocol stage)

Edaravone for acute intracerebral haemorrhage (protocol stage)

Edaravone for acute ischaemic stroke (protocol stage)

Education and counselling for promoting adherence to the treatment of active tuberculosis (protocol stage)

Education programmes for people with diabetic kidney disease (protocol stage)

Educational interventions for healthcare professionals to prevent pressure ulcers (protocol stage)

Educational interventions for improving the communication skills of general practice trainees in the clinical consultation (protocol stage)

Educational interventions for the management of cancer-related fatigue in adults (protocol stage)

Educational programmes for skin cancer prevention (protocol stage)

Efavirenz versus nevirapine as a non-nucleoside reverse transcriptase inhibitor in initial combination antiretroviral therapy for HIV infection (protocol stage)

Effect of adrenergic agonist oral decongestants on blood pressure (protocol stage)

Effect of amphetamines on blood pressure (protocol stage)

Effect of cyclosporine on blood pressure (protocol stage)

Effect of preventive interventions for malaria on HIV-1 disease progression in non-pregnant adults (protocol stage)

Effectiveness and cost-effectiveness of home palliative care services for adults with advanced illness and their caregivers (protocol stage)

Effectiveness and safety of finasteride in male chronic pelvic pain syndrome (protocol stage)

Effectiveness and safety of first-line fixed-dose TNF + EMC + EFZ for patients with HIV (protocol stage)

Effectiveness and safety of HIV post-exposure prophylaxis after sexual, injecting-drug-use or other non-occupational exposure. (protocol stage)

Effectiveness and safety of topiramate for drug dependents (protocol stage)

Effectiveness of different treatment modalities for the management of adult onset granulosa cell tumours of the ovary (primary and recurrent) (protocol stage)

Effectiveness of knowledge translation interventions to improve cancer pain management (protocol stage)

Effectiveness of staffing models in residential/subacute/extended aged care settings. (protocol stage)

Effects and safety of periconceptional folate supplementation for preventing birth defects (protocol stage)

Effects of communicating DNA-based disease risk estimates on risk-reducing behaviours (protocol stage)

Effects of creatine and analogues on blood pressure (protocol stage)

Effects of different bearing surface materials on aseptic loosening of total hip arthroplasty in patients with osteoarthritis and other non-traumatic diseases of the hip. (protocol stage)

Effects of the duration of androgen deprivation therapy for localized or locally advanced prostate cancer in patients treated with radiotherapy (protocol stage)

Efficacy and safety of vardenafil in men with diabetes and erectile dysfunction (protocol stage)

Efficacy of Psychostimulant Drugs for Cocaine Dependence (protocol stage)

Electrical stimulation for chronic wounds (protocol stage)

Electrical stimulation with non-implanted electrodes for urinary incontinence in adults (protocol stage)

Electromagnetic treatment for urinary incontinence in adults (protocol stage)

Elimination of cows' milk protein from infant diet for the treatment of infantile colic (protocol stage)

Email for clinical communication between healthcare professionals (protocol stage)

Email for clinical communication between patients/caregivers and healthcare professionals (protocol stage)

Email for communicating results of diagnostic medical investigations to patients (protocol stage)

Email for the management of healthcare appointments and attendance reminders (protocol stage)

Email for the provision of information on disease prevention and health promotion (protocol stage)

Embolisation therapy for pulmonary arteriovenous malformations (protocol stage)

Embryo transfer catheters for ART cycles (protocol stage)

Emergency sclerotherapy or band ligation combined with vasoactive drugs for bleeding esophageal varices in cirrhosis (protocol stage)

Enamel etching for bonding fixed orthodontic braces (protocol stage)

End-of-life care pathways for improving outcomes in caring for the dying (protocol stage)

Endoluminal stents for superficial femoral and popliteal artery occlusions in patients with lower limb peripheral artery disease (protocol stage)

Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes (protocol stage)

Endonasal versus external dacryocystorhinostomy for nasolacrimal duct obstruction (protocol stage)

Endoscopic interventions for unresectable cholangiocarcinoma (protocol stage)

Endoscopic or surgical intervention for painful obstructive chronic pancreatitis (protocol stage)

Endoscopic therapy for patients with gastro-esophageal reflux disease (GORD) (protocol stage)

Endoscopic treatment with or without stenting for the management of ureteric calculi (protocol stage)

Endoscopic versus medical therapy for recurrent bleeding from peptic ulcer associated with an adherent clot (protocol stage)

Endotracheal intubation versus face mask for newborns resuscitated with positive pressure ventilation at birth (protocol stage)

Endovascular repair of abdominal aortic aneurysm (protocol stage)

Endovascular versus conventional treatment for type B aortic dissection (protocol stage)

Endovenous ablation (radiofrequency and laser) and foam sclerotherapy versus conventional surgery for long saphenous vein varices (protocol stage)

Energy source instruments for laparoscopic colectomy (protocol stage)

Enhanced care by generalists for functional somatic symptoms and disorders in primary care (protocol stage)

Enhanced external counterpulsation for chronic angina pectoris (protocol stage)

Enhanced glycemic control for preventing and treating diabetic neuropathy (protocol stage)

Entecavir for chronic hepatitis B (protocol stage)

Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy (protocol stage)

Enteral nutritional supplementation with arginine for critically ill patients (protocol stage)

Enzyme replacement therapy for Anderson-Fabry disease (protocol stage)

Epidermal growth factor receptor (EGF-R) inhibitors for metastatic colorectal cancer (protocol stage)

Epidermal growth factor receptor blockers for the treatment of ovarian cancer (protocol stage)

Epidural analgesia for cardiac surgery (protocol stage)

Erlotinib for advanced non-small cell lung cancer (protocol stage)

Erythropoiesis-stimulating agents for anaemia in chronic heart failure patients (protocol stage)

Erythropoietin for anemia in rheumatoid arthritis (protocol stage)

Ethamsylate for the prevention of morbidity and mortality in preterm or very low birth weight infants (protocol stage)

Evaluation of follow-up strategies for patients with epithelial ovarian cancer following completion of primary treatment (protocol stage)

Evaluation of the efficacy and safety of adjuvant treatment to levodopa therapy in Parkinson´s disease patients with motor complications (protocol stage)

Evening Primrose Oil or other essential fatty acids for the treatment of pre-menstrual syndrome (PMS) (protocol stage)

Exchange transfusion for neonatal jaundice (protocol stage)

Excimer laser refractive surgery versus phakic intraocular lenses for the correction of moderate to high myopia (protocol stage)

Exercise for dysmenorrhoea (protocol stage)

Exercise for older depressed people (protocol stage)

Exercise for oppositional defiant disorder and conduct disorder in children and adolescents (protocol stage)

Exercise for positive mental health outcomes in adults (protocol stage)

Exercise for treating isolated meniscal injuries of the knee in adults (protocol stage)

Exercise Interventions for upper limb dysfunction due to Breast Cancer (protocol stage)

Exercise interventions on health related quality of life for cancer survivors (protocol stage)

Exercise therapy for schizophrenia (protocol stage)

Exercise therapy for the rheumatoid hand (protocol stage)

Exercise training for adults with chronic kidney disease (protocol stage)

Exercises for adolescent idiopathic scoliosis (protocol stage)

Exercises for prevention of recurrences of low-back pain (protocol stage)

Extended-release metformin versus immediate-release metformin for type 2 diabetes mellitus (protocol stage)

Extracorporeal blood purification for organophosphorus pesticide poisoning (protocol stage)

Extracranial-intracranial arterial bypass surgery for occlusive carotideal cerebrovascular disease (protocol stage)

Ezetimibe for primary hypercholesterolemia (protocol stage)

Families and Schools Together (FAST) for improving outcomes of school-aged children and their families (protocol stage)

Family based interventions to improve outcomes in patients with type 2 diabetes mellitus (protocol stage)

Family Group Decision Making for children at risk of abuse and neglect (protocol stage)

Family therapy for anorexia nervosa (protocol stage)

Family therapy for children who have been physically abused (protocol stage)

Fast track surgery versus conventional recovery strategies for colorectal surgery (protocol stage)

Female condom for preventing HIV and sexually transmitted infections (protocol stage)

Fentanyl for chronic pain (protocol stage)

Fentanyl for pain relief in burn patients (protocol stage)

Fermented milk for hypertension (protocol stage)

Fetal and umbilical Doppler ultrasound in high-risk pregnancies (protocol stage)

Fibrinolytic agents for peripheral arterial occlusion (protocol stage)

Finasteride for benign prostatic hyperplasia (protocol stage)

First-line diuretics versus other classes of antihypertensive drugs for hypertension (protocol stage)

First-line double high-dose chemotherapy and autologous stem cell transplantation versus single high-dose chemotherapy and autologous stem cell transplantation in multiple myeloma (protocol stage)

First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive drug classes for hypertension (protocol stage)

First-line stem cell transplantation from related donors compared to immunosuppressive treatment for acquired severe aplastic anaemia (protocol stage)

Flavonoids for treating venous leg ulcers (protocol stage)

Flexible working conditions and their effects on employee health and wellbeing (protocol stage)

Fluid and diuretic therapy for preventing cisplatin-induced nephrotoxicity (protocol stage)

Fluid restriction and prophylactic indomethacin versus prophylactic indomethacin alone for prevention of morbidity and mortality in extremely low birth weight infants (protocol stage)

Fluid restriction for symptomatic patent ductus arteriosus in preterm infants (protocol stage)

Fluid restriction for treatment of preterm babies with chronic lung disease (protocol stage)

Fluid therapy for pneumonia (protocol stage)

Flunarizine for the prevention of migraine (protocol stage)

Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children (protocol stage)

Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents (protocol stage)

Fluoxetine for overweight and obesity (protocol stage)

Fluoxetine for tics in Gilles de la Tourette's syndrome (protocol stage)

Fluvoxamine versus other anti-depressive agents for depression (protocol stage)

Folate supplementation in pregnancy (protocol stage)

Follicular flushing during oocyte retrieval in assisted reproductive techniques (protocol stage)

Foscarnet for chronic hepatitis B (protocol stage)

Fresh frozen plasma for cardiovascular surgery (protocol stage)

FTY720 immunosuppression for kidney transplant recipients (protocol stage)

Fumaric acid esters for psoriasis (protocol stage)

Functional analysis-based interventions for challenging behaviour in dementia (protocol stage)

Functional Family Therapy for families of youth (age 11-18) with behaviour problems (protocol stage)

Gabapentin for chronic neuropathic pain in adults (protocol stage)

Gabapentin monotherapy for epilepsy (protocol stage)

Gamma aminobutyric acid (GABA) modulators for amyotrophic lateral sclerosis/motor neuron disease (protocol stage)

Gamma-hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses (protocol stage)

Gamma-interferon for chronic hepatitis B (protocol stage)

Ganoderma Lucidum (Reishi mushroom) for cancer treatment (protocol stage)

Ganoderma lucidum for the treatment of cardiovascular risk factors (protocol stage)

Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients (protocol stage)

Gefitinib for advanced non-small cell lung cancer (protocol stage)

Gemcitabine for lung cancer (protocol stage)

Gene therapy for peripheral arterial disease (protocol stage)

Gene therapy for sickle cell disease (protocol stage)

General versus loco-regional anaesthesia for endovascular aneurysm repair (protocol stage)

Genital ulcer disease treatment for reducing sexual transmission of HIV (protocol stage)

Genotypic antiretroviral resistance testing at viral failure in people with HIV (protocol stage)

Ginkgo biloba for cognitive improvement in healthy individuals (protocol stage)

Ginseng for cognition (protocol stage)

Gloves, gowns and masks for reducing the transmission of meticillin-resistant Staphylococcus aureus (MRSA) in the hospital setting. (protocol stage)

Glucagon-like peptide analogues for type 2 diabetes mellitus (protocol stage)

Glucocorticoid supplementation during ovarian stimulation for IVF or ICSI (protocol stage)

Glucocorticoid with cyclophosphamide for paraquat-induced lung fibrosis (protocol stage)

Glucocorticoids for the treatment of anaphylaxis (protocol stage)

Glucocorticosteroids for alcoholic hepatitis (protocol stage)

Glucocorticosteroids for liver transplanted patients (protocol stage)

Glucocorticosteroids for viral hepatitis B (protocol stage)

Glucose-insulin-potassium (GIK) and Tight-glycaemic-control (TGC) versus standard therapy insulin for critically ill patients (protocol stage)

Glutamine for induction of remission in Crohn's disease (protocol stage)

Glutamine supplementation in enteral or parenteral nutrition for the incidence of mucositis in colorectal cancer (protocol stage)

Gonadotrophin-releasing hormone agonist protocols for pituitary suppression in assisted reproductive treatment (protocol stage)

Gonadotrophin-releasing hormone analogues for hirsutism (protocol stage)

Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist assisted reproductive technology cycles (protocol stage)

Group versus conventional antenatal care for pregnant women (protocol stage)

Group visits as part of ongoing care for improving health (protocol stage)

Growth factors for chronic kidney disease in adults (protocol stage)

H1 antihistamines for eczema (protocol stage)

H1-antihistamines for chronic urticaria (protocol stage)

Haemodialysis for lithium poisoning (protocol stage)

Haemodilution for retinal vein occlusion (protocol stage)

Haemostatic drugs for traumatic brain injury (protocol stage)

Hand Assisted Laparoscopic Surgery versus Conventional Laparoscopy for Colorectal Surgery (protocol stage)

Hands-on therapy interventions for upper limb motor dysfunction following stroke (protocol stage)

Harm reduction interventions to prevent HIV/AIDS transmission in involuntary detainees (protocol stage)

Harmonic scalpel versus other surgical procedures for tonsillectomy (protocol stage)

Health examination for the prevention of occupational injury and disease in workers (protocol stage)

Heated CO2 with or without humidification for minimally invasive abdominal surgery (protocol stage)

Heated humidification versus heat and moisture exchangers for ventilated adults and children (protocol stage)

Helicobacter pylori eradication for premalignant lesions of the gastric mucosa (protocol stage)

Helicobacter pylori eradication for the prevention of gastric neoplasia (protocol stage)

Heliox for croup in children (protocol stage)

Heliox for prevention of morbidity and mortality in ventilated newborn infants (protocol stage)

Heliox inhalation therapy for bronchiolitis in infants (protocol stage)

Hematopoietic Growth Factors in the Treatment of Acquired Aplastic Anemia (protocol stage)

Heparin and related substances for delaying the progression of diabetic kidney disease (protocol stage)

Heparin and related substances for preventing diabetic kidney disease (protocol stage)

Heparin for ST-segment elevation myocardial infarction (protocol stage)

Heparin versus normal saline for patency of arterial lines (protocol stage)

Hepatitis B immune globulin for prevention of posttransplantation hepatitis B (protocol stage)

Hepatitis B vaccination during pregnancy for preventing infant infection (protocol stage)

Herbal medicine for chronic neck pain due to cervical degenerative disc disease (protocol stage)

Herbal medicine for diabetic retinopathy (protocol stage)

Herbal medicine for relapse and metastasis in patients operated for colorectal cancer (protocol stage)

Herbal medicines for advanced colorectal cancer (protocol stage)

Herbal medicines for systemic lupus erythematosus (protocol stage)

Herbal medicines for treating osteoporosis (protocol stage)

Herbal medicines for type 1 diabetes mellitus (protocol stage)

High carbohydrate, high protein, low fat versus low carbohydrate, high protein, high fat enteral feeds for burns (protocol stage)

High concentration versus low concentration sevoflurane for anaesthesia induction (protocol stage)

High dose chemotherapy and autologous stem cell rescue for children with high risk neuroblastoma (protocol stage)

High dose chemotherapy for children and young adults with stage IV rhabdomyosarcoma (protocol stage)

High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer (protocol stage)

High dose versus low dose intravesical interferon-alpha 2b for the treatment of carcinoma in situ of the bladder (protocol stage)

High dose versus low dose oxytocin for augmentation of labour (protocol stage)

High feedback versus low feedback of routine prenatal ultrasound for improving outcomes (protocol stage)

High flow nasal cannula for respiratory support in preterm infants (protocol stage)

High versus low amino acid intake at the commencement of parenteral nutrition to improve growth in neonates receiving intensive care (protocol stage)

High versus low thresholds for repeat administration of surfactant in intubated preterm neonates (protocol stage)

High versus standard protein content of human milk fortifier for promoting growth and neurological development in preterm infants (protocol stage)

High vs low dose conventional phototherapy for neonatal jaundice (protocol stage)

High-dose chemotherapy with autologous stem cell support for first-line treatment of aggressive non-Hodgkin lymphoma: a systematic review and meta-analysis based on individual patient data (protocol stage)

High-flux versus low-flux membranes for end-stage kidney disease (protocol stage)

High-volume haemofiltration for sepsis (protocol stage)

Higher versus lower humidity for the prevention of morbidity and mortality in preterm infants in incubators (protocol stage)

Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer (protocol stage)

Home based child development interventions for pre-school children from socially disadvantaged families (protocol stage)

Home based, parent mediated, early educational intervention for children with, or biologically at risk of, developmental disability (protocol stage)

Home uterine monitoring for detecting preterm labour (protocol stage)

Home-based care for reducing morbidity and mortality in people infected with HIV/AIDS (protocol stage)

Home-based exercise therapy for rheumatoid arthritis (protocol stage)

Home-based palliative care for adults with cancer (protocol stage)

Home-based post-discharge parental support to prevent morbidity in preterm infants (protocol stage)

Home-based therapy programmes for upper limb functional recovery following stroke (protocol stage)

Home-based versus centre-based cardiac rehabilitation (protocol stage)

Home-use whitening toothpastes for removal and prevention of stains in adults (protocol stage)

Homeopathic remedies for acute respiratory tract infections in children (protocol stage)

Homeopathy for osteoarthritis (protocol stage)

Honey for acute cough in children (protocol stage)

Hormone replacement therapy for osteoarthritis in peri-menopausal and post-menopausal women (protocol stage)

Hormone therapy for advanced or recurrent endometrial cancer (protocol stage)

Hospital nurse staffing models and patient and staff-related outcomes (protocol stage)

How effects on health equity are assessed in systematic reviews of interventions (protocol stage)

HPV testing versus cervical cytology for screening for cancer of the uterine cervix (protocol stage)

Huangqi preparation for unstable angina (protocol stage)

Human albumin for intradialytic hypotension in haemodialysis patients (protocol stage)

Human chorionic gonadotrophin for threatened miscarriage (protocol stage)

Human growth hormone and glutamine for patients with short bowel syndrome (protocol stage)

Human parathyroid hormone for the treatment of osteoporosis in post-menopausal women. (protocol stage)

Humidification of inspired air in exercise-induced asthma (protocol stage)

Hydralazine for essential hypertension (protocol stage)

Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function (protocol stage)

Hydroxyzine for generalised anxiety disorder (protocol stage)

Hyperbaric oxygen therapy for acute surgical and traumatic wounds (protocol stage)

Hyperbaric oxygen therapy for Bell's palsy (protocol stage)

Hyperfractionated or accelerated radiotherapy in head and neck cancer (protocol stage)

Hypertonic saline for peri-operative fluid management (protocol stage)

Hypnosis for children undergoing dental treatment (protocol stage)

Hypolipidemic and antihypertensive drugs for prevention of cardiovascular complications in patients with rheumatoid arthritis (protocol stage)

Ibandronate sodium for osteoporosis in postmenopausal women (protocol stage)

Ibuprofen for pain relief after surgical removal of lower wisdom teeth (protocol stage)

Ibuprofen versus paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth (protocol stage)

Ibuprofen with or without an antiemetic for acute migraine in adults (protocol stage)

Imatinib mesylate for gastrointestinal stromal tumours (GISTs) (protocol stage)

Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy (protocol stage)

Immunochromatography-based rapid diagnostic tests for diagnosing uncomplicated malaria in endemic countries (protocol stage)

Immunonutrition as an adjuvant therapy for burns (protocol stage)

Immunosuppressants for the prophylaxis of corneal graft rejection after penetrating keratoplasty (protocol stage)

Immunosuppressive T cell antibodies for liver transplant recipients (protocol stage)

Impact of shared scientific or ethical review of multicentre clinical research on the quality of clinical research and the clinical research process (protocol stage)

Implantable defibrillator versus pharmacotherapy for Brugada syndrome (protocol stage)

Improving surgical practice - a systematic review of effective education strategies to improve surgical technical skills in operative procedures (protocol stage)

In-service training for health professionals to improve care of the seriously ill newborn or child in low and middle-income countries (Review) (protocol stage)

Incentives for improving patient adherence to anti-tuberculosis treatment (protocol stage)

Incision and drainage of perianal abscess with or without treatment of anal fistula (protocol stage)

Increased versus stable doses of inhaled steroids for exacerbations of chronic asthma in adults and children (protocol stage)

Increasing motorcycle and rider conspicuity for preventing death and injury in motorcyclists (protocol stage)

Individual patient data meta-analyses compared with meta-analyses based on aggregate data (protocol stage)

Indoor residual spraying for preventing malaria (protocol stage)

Inferior turbinate surgery for nasal obstruction in allergic rhinitis after failed medical treatment (protocol stage)

Influenza vaccine for preventing acute otitis media in infants and children (protocol stage)

Information and support interventions for informal caregivers of people with dementia (protocol stage)

Infraclavicular brachial plexus block for regional anaesthesia of the lower arm (protocol stage)

Inhaled corticosteroids versus long acting beta-agonists for chronic obstructive pulmonary disease (protocol stage)

Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis (protocol stage)

Initial arch wires for alignment of crooked teeth with fixed orthodontic braces (protocol stage)

Injectable local anaesthetic agents for operative dental anaesthesia (protocol stage)

Instruments for assessing readiness to commence suck feeds in preterm infants: effects on time to establish full oral feeding and duration of hospitalisation (protocol stage)

Instruments for assisted vaginal delivery (protocol stage)

Insulin for glycaemic control in acute ischaemic stroke (protocol stage)

Insulin-sensitising therapies for preventing the progression of diabetic kidney disease (protocol stage)

Intensity and type of exercise for lower limb endurance training to optimise exercise capacity for people with chronic obstructive pulmonary disease (protocol stage)

Intensive Case Management for severe mental illness (protocol stage)

Intensive insulin therapy and strict glucose control for critically ill patients (protocol stage)

Intensive versus standard haemodialysis water treatment for preventing low grade mineral intoxication in chronic haemodialysed patients (protocol stage)

Interactive computer-based interventions for sexual health promotion (protocol stage)

Interferon beta for chronic hepatitis B (protocol stage)

Interferon beta for secondary progressive multiple sclerosis (protocol stage)

Interferon for anogenital warts in non-immunocompromised adults (protocol stage)

Interferon for hepatocellular carcinoma (protocol stage)

Interferon-alpha for hepatitis D (protocol stage)

Interferon-alpha for maintenance of follicular lymphoma (protocol stage)

Interleukin-1 receptor antagonist for treating periodontitis (protocol stage)

Intermittent drug techniques for schizophrenia (protocol stage)

Intermittent phototherapy versus continuous phototherapy for neonatal jaundice (protocol stage)

Intermittent preventive treatment regimens for malaria in HIV-positive pregnant women (protocol stage)

Intermittent versus daily therapy for treating tuberculosis in children (protocol stage)

Internal fixation and comparisons of different fixation methods for treating distal radial fractures in adults (protocol stage)

Internal versus external fixation for treating distal tibial pilon fractures in adults (protocol stage)

Internet-based interventions for smoking cessation (protocol stage)

Interposition vein cuff for infragenicular prosthetic bypass graft (protocol stage)

Intervention aimed at improving professional adherence to guidelines for prevention of device-related infections (protocol stage)

Intervention for replacing missing teeth: Effect of type of implant-supported prostheses used to rehabilitate completely edentulous patients on treatment outcomes. (protocol stage)

Interventions (non-pharmacological) for preparing children and adolescents for hospital care (protocol stage)

Interventions at caesarean section for reducing aspiration pneumonitis (protocol stage)

Interventions for actinic keratoses (protocol stage)

Interventions for acute internal hordeolum (protocol stage)

Interventions for acute otitis externa (protocol stage)

Interventions for adherence to pulmonary rehabilitation for chronic obstructive pulmonary disease (protocol stage)

Interventions for androgenic alopecia in women (protocol stage)

Interventions for blepharitis (protocol stage)

Interventions for Bowen's Disease (protocol stage)

Interventions for cellulitis and erysipelas (protocol stage)

Interventions for clinical and subclinical hypothyroidism in pregnancy (protocol stage)

Interventions for controlling emigration of health professionals from low and middle-income countries (protocol stage)

Interventions for cough in malignant disease (protocol stage)

Interventions for covert bacteriuria in children (protocol stage)

Interventions for cutaneous disease in systemic lupus erythematosus (protocol stage)

Interventions for cutaneous lichen planus (protocol stage)

Interventions for decreasing postoperative pain following refractive excimer laser surface ablation of the cornea (protocol stage)

Interventions for dialysis patients with hepatitis C virus (HCV) infection (protocol stage)

Interventions for dialysis-associated restless legs syndrome (protocol stage)

Interventions for enhancing the skills of consumers to find, evaluate and use online health information (protocol stage)

Interventions for erosive lichen planus affecting mucosal sites (protocol stage)

Interventions for erythropoietin-resistant anaemia in dialysis patients (protocol stage)

Interventions for fatigue in peripheral neuropathy (protocol stage)

Interventions for fatigue management after traumatic brain injury (protocol stage)

Interventions for ganglion cysts in adults (protocol stage)

Interventions for hand eczema (protocol stage)

Interventions for helping people recognise early signs of recurrence in depression (protocol stage)

Interventions for iatrogenic inferior alveolar and lingual nerve injury (protocol stage)

Interventions for iatrogenic lingual nerve injury (protocol stage)

Interventions for idiopathic membranoproliferative glomerulonephritis (protocol stage)

Interventions for improving coverage of child immunization in low-income and middle-income countries (protocol stage)

Interventions for improving outcomes in patients with multimorbidity in primary care and community settings (protocol stage)

Interventions for improving palliative care for older people living in nursing care homes (protocol stage)

Interventions for improving sit-to-stand ability in patients with stroke (protocol stage)

Interventions for improving the adoption of shared decision making by healthcare professionals (protocol stage)

Interventions for improving the appropriate use of imaging in people with musculoskeletal conditions (protocol stage)

Interventions for improving understanding and minimising the psychological impact of screening (protocol stage)

Interventions for improving uptake of population-based screening for colorectal cancer using fecal occult blood testing (protocol stage)

Interventions for increasing ankle range of motion in patients with neuromuscular disease (protocol stage)

Interventions for infantile haemangiomas (protocol stage)

Interventions for late trabeculectomy bleb leak (protocol stage)

Interventions for localised excessive sweating (protocol stage)

Interventions for lowering plasma homocysteine levels in dialysis patients (protocol stage)

Interventions for lowering plasma homocysteine levels in kidney transplant recipients (protocol stage)

Interventions for melasma (protocol stage)

Interventions for mood and anxiety disorders, and self harm in young offenders (protocol stage)

Interventions for Mooren's ulcer (protocol stage)

Interventions for morphea (protocol stage)

Interventions for nail psoriasis (protocol stage)

Interventions for nausea and vomiting in early pregnancy (protocol stage)

Interventions for neovascular age-related macular degeneration (protocol stage)

Interventions for non-metastatic squamous cell carcinoma of the skin (protocol stage)

Interventions for obsessive compulsive symptoms in people with schizophrenia (protocol stage)

Interventions for pes planus (protocol stage)

Interventions for polymorphic light eruption (protocol stage)

Interventions for preventing allergic and febrile non-haemolytic transfusion reactions (protocol stage)

Interventions for preventing and reducing the use of physical restraints in long-term geriatric care (protocol stage)

Interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy (protocol stage)

Interventions for preventing excessive weight gain during pregnancy (protocol stage)

Interventions for preventing falls in older people in nursing care facilities and hospitals (protocol stage)

Interventions for preventing haemolytic uraemic syndrome/thrombotic thrombocytopenic purpura (protocol stage)

Interventions for preventing hamstring injuries (protocol stage)

Interventions for preventing hypotension in adults receiving spinal anaesthesia (protocol stage)

Interventions for preventing infectious complications in haemodialysis patients with central venous lines (protocol stage)

Interventions for preventing injuries caused by impaired alertness in individuals who are not sleep deprived (protocol stage)

Interventions for preventing injuries caused by impaired alertness in individuals who are sleep deprived (protocol stage)

Interventions for preventing injuries caused by impaired alertness in individuals with jet lag and shift work disorder (protocol stage)

Interventions for preventing mastitis after childbirth (protocol stage)

Interventions for preventing occupational irritant hand dermatitis (protocol stage)

Interventions for preventing ophthalmia neonatorum (protocol stage)

Interventions for preventing pre-eclampsia and its consequences: generic protocol (protocol stage)

Interventions for preventing relapse and recurrence after the first episode of a depressive disorder in young people (protocol stage)

Interventions for preventing thrombosis in adults and children with nephrotic syndrome (protocol stage)

Interventions for promoting the use of advance directives for end-of-life decisions in adults (protocol stage)

Interventions for psychosis in adolescents (protocol stage)

Interventions for recurrent aphthous stomatitis (mouth ulcers) (protocol stage)

Interventions for reducing medication errors in children in hospital (protocol stage)

Interventions for reducing nausea and vomiting at caesarean section (protocol stage)

Interventions for reduction of stigma in people with HIV/AIDS (protocol stage)

Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (protocol stage)

Interventions for replacing missing teeth: partially absent dentition (protocol stage)

Interventions for replacing missing teeth: resin-bonded bridges and other restorations for the replacement of adult teeth (protocol stage)

Interventions for restoring patency of occluded central venous catheter lumens (protocol stage)

Interventions for seborrhoeic dermatitis (protocol stage)

Interventions for sensory impairment in the upper limb after stroke (protocol stage)

Interventions for smoking cessation and reduction in individuals with schizophrenia (protocol stage)

Interventions for space closure in orthodontic treatment (protocol stage)

Interventions for supporting informal caregivers of patients in the terminal phase of a disease (protocol stage)

Interventions for the management of external root resorption (protocol stage)

Interventions for the management of post-endodontic pain (protocol stage)

Interventions for the management of temporomandibular joint osteoarthritis (protocol stage)

Interventions for the prevention of mycobacterium avium complex in adults and children with HIV (protocol stage)

Interventions for the prevention of relationship and dating violence in adolescents and young people (protocol stage)

Interventions for the restorative care of amelogenesis imperfecta in children and adolescents (protocol stage)

Interventions for the treatment of borderline ovarian tumours (protocol stage)

Interventions for the treatment of fractures of the mandibular condyle (protocol stage)

Interventions for the treatment of oral and oropharyngeal cancer: chemotherapy (protocol stage)

Interventions for the treatment of oral and oropharyngeal cancers: immunotherapy/biotherapy (protocol stage)

Interventions for the treatment of oral cancer (protocol stage)

Interventions for the treatment of oral cancer: radiotherapy (protocol stage)

Interventions for treating acute elbow dislocations in adults (protocol stage)

Interventions for treating acute fractures of the carpal scaphoid bone in adults (protocol stage)

Interventions for treating ameloblastomas of the jaws (protocol stage)

Interventions for treating burn itch (protocol stage)

Interventions for treating denture stomatitis (protocol stage)

Interventions for treating keloid disease (protocol stage)

Interventions for treating oral haemangiomas in adults (protocol stage)

Interventions for treating osteoarthritis of the big toe joint (protocol stage)

Interventions for treating osteochondral defects of the talus in adults (protocol stage)

Interventions for treating painful nipples among breastfeeding women (protocol stage)

Interventions for treating pre-eclampsia and its consequences: generic protocol (protocol stage)

Interventions for treating sexual dysfunction in patients with chronic kidney disease (protocol stage)

Interventions for treating traumatised ankylosed permanent front teeth (protocol stage)

Interventions for treating traumatised non-vital immature permanent front teeth: inducing a calcific barrier and root strengthening (protocol stage)

Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted (protocol stage)

Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth (protocol stage)

Interventions for treating traumatised permanent front teeth: root fracture (protocol stage)

Interventions in primary care to reduce medication related adverse events and hospital admissions (protocol stage)

Interventions other than anticoagulants and systemic antibiotics for prevention of central venous catheter related infections in children with cancer (protocol stage)

Interventions to enhance return-to-work for cancer patients (protocol stage)

Interventions to improve adherence to exercise for chronic musculoskeletal pain in adults (protocol stage)

Interventions to improve continuity of care in the follow-up of patients with cancer (protocol stage)

Interventions to improve evidence-based prescribing for heart failure (protocol stage)

Interventions to improve excreta disposal for preventing diarrhoea (protocol stage)

Interventions to improve question formulation in professional practice and self-directed learning (protocol stage)

Interventions to improve the appropriate use of polypharmacy for older people (protocol stage)

Interventions to improve the management of asthma in primary care settings (protocol stage)

Interventions to increase clinical incident reporting in health care (protocol stage)

Interventions to increase influenza vaccination rates of those 60 years and older in the community and in institutions (protocol stage)

Interventions to increase the use of screening and brief intervention programmes for hazardous alcohol consumption by patients in primary care settings (protocol stage)

Interventions to modify sexual risk behaviours for preventing HIV in homeless youth (protocol stage)

Interventions to promote screening for diabetic retinopathy (protocol stage)

Interventions to reduce waiting lists for elective procedures (protocol stage)

Interventions to slow progression of myopia in children (protocol stage)

Interventions to support children through bereavement (protocol stage)

Interventions used in Emergency Departments (ED) for pain management of simple fractures in children (protocol stage)

Intra-amniotic surfactant for women at risk of preterm birth for preventing respiratory distress in newborns (protocol stage)

Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock (protocol stage)

Intra-articular lignocaine versus intravenous analgesia with or without sedation for manual reduction of acute anterior shoulder dislocation in adults (protocol stage)

Intra-peritoneal local anaesthetic instillation for laparoscopic cholecystectomy (protocol stage)

Intra-peritoneal saline instillation versus no instillation for laparoscopic cholecystectomy (protocol stage)

Intramuscular versus intravenous anti-D for preventing Rhesus alloimmunization during pregnancy (protocol stage)

Intraoperative 5-Fluorouracil for glaucoma surgery (protocol stage)

Intraoperative blood salvage for penetrating abdominal and thoracic trauma (protocol stage)

Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace (protocol stage)

Intraperitoneal chemotherapy for gastric carcinoma (protocol stage)

Intrathecal baclofen for treating spasticity in children with cerebral palsy (protocol stage)

Intratympanic glucocorticoids for sudden sensorineural hearing loss (protocol stage)

Intravenous alpha-1 antitrypsin augmentation therapy for treating patients with alpha-1 antitrypsin deficiency and lung disease (protocol stage)

Intravenous fluid therapy for management of acute infections (protocol stage)

Intravenous fluids for preventing dehydration and prolonged labour in nulliparous women (protocol stage)

Intravenous immunoglobulin for juvenile idiopathic arthritis (protocol stage)

Intravesical Bacillus Calmette-Guérin versus epirubicin for Ta and T1 bladder cancer (protocol stage)

Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery (protocol stage)

Involving service users as researchers for the evaluation of adult statutory mental health services (protocol stage)

Involving service users as service providers for adult statutory mental health services (protocol stage)

Involving service users as trainers for professionals working in adult statutory mental health services (protocol stage)

Ipratropium bromide for stable chronic obstructive pulmonary disease (protocol stage)

Iridectomy or iridotomy for preventing angle-closure glaucoma (protocol stage)

Iron for restless legs syndrome (protocol stage)

Iron nutriture for colorectal cancer (protocol stage)

Iron supplementation for breath-holding attacks in children (protocol stage)

Iron supplementation for improving psychomotor development and cognitive function in infants under the age of one (protocol stage)

Iron supplementation for iron deficiency anemia in children (protocol stage)

Iron supplementation in enterally fed preterm infants (protocol stage)

Isokinetic exercise for improving knee flexor and extensor muscles (protocol stage)

Isolation as a strategy for controlling the transmission of hepatitis C virus (HCV) infection in haemodialysis units (protocol stage)

Isoniazid monotherapy versus other monotherapies or combination chemotherapy for preventing active tuberculosis in HIV-negative persons (protocol stage)

Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis (protocol stage)

L-ornithine-L-aspartate for hepatic encephalopathy (protocol stage)

Lactose avoidance for acute diarrhoea in children less than five years (protocol stage)

Lactulose versus Polyethylene Glycol for Chronic Constipation (protocol stage)

Lamivudine for chronic hepatitis B in adults (protocol stage)

Lamivudine for preventing reactivation of hepatitis B infection in patients planned to undergo immunosuppressive therapy (protocol stage)

Lamivudine or adefovir dipivoxil alone or combined with immunoglobulin for preventing hepatitis B recurrence after liver transplantation (protocol stage)

Lamotrigine add-on for refractory generalized tonic-clonic seizures (protocol stage)

Laparoscopic ovarian diathermy versus metformin for women with polycystic ovarian syndrome (protocol stage)

Laparoscopic radical cystectomy for bladder cancer (protocol stage)

Laparoscopic versus open myomectomy for uterine fibroids (protocol stage)

Laparoscopic versus open nephrectomy for live kidney donors (protocol stage)

Laparoscopic versus Open surgery for small bowel Crohn's disease (protocol stage)

Laparoscopic versus open surgery in small bowel obstruction (protocol stage)

Laparoscopic versus open surgical techniques for ventral hernia repair (protocol stage)

Laparoscopically assisted radical vaginal hysterectomy versus abdominal radical hysterectomy for the treatment of early cervical cancer (protocol stage)

Laparoscopy versus laparotomy for the management of endometrial cancer (protocol stage)

Larger versus smaller dose of the same drug/s regimen for metastatic breast cancer (protocol stage)

Larvivorous fish for malaria prevention (protocol stage)

Laryngeal mask airway versus endotracheal tube in laparoscopic cholecystectomy in adults (protocol stage)

Laryngeal mask airway versus endotracheal tube in laparoscopic gynaecological surgery in adults (protocol stage)

Laser photocoagulation for diabetic retinopathy (protocol stage)

Laser photocoagulation versus transscleral cryotherapy for threshold retinopathy of prematurity (protocol stage)

Laser versus non-laser endonasal dacryocystorhinostomy (protocol stage)

Lasers and light sources for port-wine stains (protocol stage)

Lateral positioning for critically ill adult patients (protocol stage)

Legislative bans for reducing smoking prevalence and tobacco consumption (protocol stage)

Leucotriene receptor antagonists in addition to usual care for acute asthma in adults and children (protocol stage)

Leukotriene receptor antagonists for rhinosinusitis (protocol stage)

Levamisole for chronic hepatitis B (protocol stage)

Levodopa for restless legs syndrome (protocol stage)

Levomepromazine for schizophrenia (protocol stage)

Life-style modification, non-pharmacological and pharmacological strategies for obese subfertile women (protocol stage)

Lifestyle changes in overweight women with Polycystic Ovary Syndrome (protocol stage)

Lifestyle interventions for the treatment of urinary incontinence in adults (protocol stage)

Light therapies for acne (protocol stage)

Light-emitting diode phototherapy for unconjugated hyperbilirubinemia in neonates (protocol stage)

Linezolid versus vancomycin for skin and soft tissue infections (protocol stage)

Lipid-lowering agents for nephrotic syndrome (protocol stage)

Lithium for acute mania (protocol stage)

Local anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity (protocol stage)

Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery (protocol stage)

Local and systemic treatments for acute oedema after burn injury (protocol stage)

Local anesthetic at the iliac crest donor-site for postoperative pain management in spine surgery patients (protocol stage)

Local consensus processes: effects on professional practice and health care outcomes (protocol stage)

Local delivery antimicrobials for chronic periodontitis (protocol stage)

Local nasal immunotherapy for allergic rhinitis (protocol stage)

Local surgical treatment in early rectal cancer with or without adjuvant therapy (protocol stage)

Long term proton pump inhibitor (PPI) use and incidence of gastric (pre) malignant lesions. (protocol stage)

Long-acting beta2-agonists for chronic obstructive pulmonary disease: serious adverse events (protocol stage)

Long-acting insulin analogue versus another long-acting insulin analogue for type 2 diabetes mellitus (protocol stage)

Long-term nutritional interventions for adult kidney transplant recipients (protocol stage)

Long-term opioid management for chronic noncancer pain (protocol stage)

Loop diuretics during blood transfusion for anaemia in preterm infants (protocol stage)

Low bacterial diet to prevent infection in neutropenic patients (protocol stage)

Low dose versus high dose stavudine for treating people with HIV infection (protocol stage)

Low fat diets for acquired hypercholesterolemia (protocol stage)

Low molecular weight heparin for prevention of central venous catheterization-related thrombosis in children (protocol stage)

Low versus high hemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants (protocol stage)

Luteinising hormone releasing hormone (LHRH) analogues for children or adolescents with early puberty, idiopathic short stature or growth hormone deficiency (protocol stage)

Lycopene for the prevention of prostate cancer (protocol stage)

Lymphadenectomy for the management of endometrial cancer (protocol stage)

Macrolides for diffuse panbronchiolitis (protocol stage)

Magnesium sulfate for term infants following perinatal asphyxia (protocol stage)

Maintenance chemotherapy for ovarian cancer (protocol stage)

Maintenance treatment with antipsychotic drugs for schizophrenia (protocol stage)

Male circumcision for prevention of homosexual acquisition of HIV in men (protocol stage)

Managed alcohol as a harm reduction intervention for alcohol addiction in populations at high risk for substance abuse (protocol stage)

Management of drainage for malignant ascites in gynaecological cancer (protocol stage)

Manual paper reminders: effects on professional practice and health care outcomes (protocol stage)

Manual ventilation devices for neonatal resuscitation (protocol stage)

Masking reviewers at the study inclusion stage in a systematic review of health care interventions (protocol stage)

Massage therapy for people with HIV/AIDS (protocol stage)

Materials for retrograde filling in root canal therapy (protocol stage)

Maternal position during caesarean section for preventing maternal and neonatal complications (protocol stage)

Measles/MMR vaccine for infants born to HIV-positive mothers (protocol stage)

Mechanical chest compressions versus manual chest compressions for cardiac arrest (protocol stage)

Mechanical dilatation of the cervix at non-labour caesarean section for reducing postoperative morbidity (protocol stage)

Media-delivered cognitive behavioural therapy and behavioural therapy (self-help) for anxiety disorders in adults (protocol stage)

Medical interventions for high grade vulval intraepithelial neoplasia (protocol stage)

Medical interventions for traumatic hyphema (protocol stage)

Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer (protocol stage)

Medical interventions for treating chronic primary angle-closure glaucoma (protocol stage)

Medical methods for mid-trimester termination of pregnancy (protocol stage)

Medical methods for preventing blood loss at caesarean section (protocol stage)

Medical therapies for parenteral nutrition-associated cholestasis in term and preterm infants (protocol stage)

Medical therapy for infantile colic (protocol stage)

Medical treatment for botulism (protocol stage)

Medical treatments for autoimmune hepatitis (protocol stage)

Medical treatments for incomplete miscarriage (less than 24 weeks) (protocol stage)

Medical treatments for painful bladder syndrome (interstitial cystitis) (protocol stage)

Medical versus surgical interventions for nasal polyps (protocol stage)

Medical versus surgical management for gastro-oesphageal reflux disease (GORD) in adults (protocol stage)

Medications for increasing milk supply in mothers expressing breastmilk for their hospitalised infants (protocol stage)

Medicinal herbs for acute hepatitis B (protocol stage)

Medicinal herbs for cholelithiasis (protocol stage)

Meditation therapies for attention deficit /hyperactivity disorder (protocol stage)

Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke (protocol stage)

Mentoring of children and adolescents for preventing drug and alcohol use. (protocol stage)

Meperidine (pethidine) for treatment of postoperative pain in adults (protocol stage)

Metal versus non-metal backing of the tibial component for total knee replacement for osteoarthritis and/or rheumatoid arthritis. (protocol stage)

Methadone for chronic non-cancer pain in adults (protocol stage)

Methods for cervical ripening and labour induction in late pregnancy: generic protocol (protocol stage)

Methods for informing people with amyotrophic lateral sclerosis/motor neuron disease of their diagnosis (protocol stage)

Methods for obtaining unpublished data (protocol stage)

Methods for securing endotracheal tubes in newborn infants (protocol stage)

Methods of cystic duct occlusion during laparoscopic cholecystectomy (protocol stage)

Methods of decreasing infection after liver resections (protocol stage)

Methods of gallbladder dissection for laparoscopic cholecystectomy (protocol stage)

Methods of management of high-risk surgical patients with acute cholecystitis (protocol stage)

Methods of securing peripheral vascular catheters to reduce morbidity in neonates (protocol stage)

Methods to increase response rates for data collected by telephone (protocol stage)

Methods to influence the completeness of response to self-administered questionnaires (protocol stage)

Methotrexate for psoriasis (protocol stage)

Methylphenidate for attention-deficit/hyperactivity disorder in adults (protocol stage)

Mifepristone for uterine fibroids (protocol stage)

Milrinone for persistent pulmonary hypertension of the newborn (protocol stage)

Milrinone for the treatment of cardiac dysfunction in neonates (protocol stage)

Mind and body therapy for fibromyalgia (protocol stage)

Mind-body interventions during pregnancy for preventing or treating women's anxiety (protocol stage)

Minimally invasive surgical approaches for total hip arthroplasty in adults with osteoarthritis (protocol stage)

Miniport versus standard ports for laparoscopic cholecystectomy (protocol stage)

Minocycline for amyotrophic lateral sclerosis or motor neuron disease (protocol stage)

Mirtazapine versus other anti-depressive agents for depression (protocol stage)

Misoprostol for induction of labour to terminate pregnancy in the second or third trimester for women with a fetal anomaly or after intrauterine fetal death (protocol stage)

Mitomycin C for prevention of postoperative haze following excimer laser surface ablation in moderate to high myopia (protocol stage)

Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery (protocol stage)

Mobile phone messaging - a telemedicine for people with diabetes mellitus (protocol stage)

Mobile phone messaging for communicating results of medical investigations (protocol stage)

Mobile phone messaging for preventive health care (protocol stage)

Mobile phone messaging reminders for attendance at scheduled healthcare appointments (protocol stage)

Mobile phone messaging telemedicine for facilitating self management of long-term illnesses (protocol stage)

Mometasone for asthma in adults and children (protocol stage)

Momordica charantia for type 2 diabetes mellitus (protocol stage)

Monoclonal anti-CD20 antibodies for chronic lymphocytic leukaemia (protocol stage)

Monoclonal antibodies for preventing respiratory syncytial virus infection (protocol stage)

Monosodium glutamate avoidance for chronic asthma in adults and children (protocol stage)

Morning versus evening induction of labour for improving outcomes (protocol stage)

Motivational interviewing for smoking cessation (protocol stage)

Motivational interviewing for substance abuse (protocol stage)

Motivational interviewing for the prevention of alcohol misuse in young people (protocol stage)

Motorcycle helmet legislation for preventing injuries in motorcyclists (protocol stage)

Motorcycle rider training for the prevention of road traffic crashes (protocol stage)

Multidimensional rehabilitation programmes for adult cancer survivors (protocol stage)

Multidisciplinary interventions for the management of delirium in hospitalized patients (protocol stage)

Multidisciplinary rehabilitation and monodisciplinary rehabilitation for visually impaired adults (protocol stage)

Multiple session early psychological interventions to treat acute traumatic stress symptoms (protocol stage)

Muscle relaxants versus placebo for tension-type headache prophylaxis (protocol stage)

Muscle strengthening for children and adults with cerebral palsy (protocol stage)

Music for preoperative anxiety (protocol stage)

Music interventions for improving psychological and physical outcomes in cancer patients (protocol stage)

Music interventions for mechanically ventilated patients (protocol stage)

Music therapy for acquired brain injury (protocol stage)

Music therapy for end-of-life care (protocol stage)

Mycophenolate mofetil for liver-transplanted patients (protocol stage)

Mycophenolic acid versus azathioprine as primary immunosuppression for kidney transplant recipients (protocol stage)

Myeloablative high-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults (protocol stage)

N-acetylcysteine for sepsis and systemic inflammatory response in adults (protocol stage)

Naftidrofuryl for dementia (protocol stage)

Naloxone for hepatic encephalopathy (protocol stage)

Natalizumab for relapsing remitting multiple sclerosis (protocol stage)

Natriuretic peptides for acute heart failure syndromes (protocol stage)

Nebulised colistin for nosocomial Acinetobacter baumannii respiratory tract infection (protocol stage)

Nebuliser devices for drug delivery in cystic fibrosis (protocol stage)

Nebulisers versus all hand-held inhalers to deliver bronchodilators in chronic obstructive pulmonary disease (protocol stage)

Nebulisers versus hand-held inhalers to deliver beta2-agonist bronchodilator drugs in non-acute asthma (protocol stage)

Nebulized epinephrine for croup in children (protocol stage)

Negative versus positive framing of the health information message (protocol stage)

Neoadjuvant chemotherapy for patients having resection or ablation of liver metastases from colorectal cancer. (protocol stage)

Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer (protocol stage)

Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in developing countries (protocol stage)

Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis (protocol stage)

Neuraxial anaesthesia for lower-limb revascularization (protocol stage)

Neurokinin-1 receptor antagonists for prevention of chemotherapy-related nausea and vomiting in adults (protocol stage)

Neuroprotection for prevention and treatment of glaucoma in adults (protocol stage)

Neurosurgery for obsessive-compulsive disorder, other anxiety disorders and depressive disorders (protocol stage)

Neurosurgical interventions for the treatment of classical trigeminal neuralgia (protocol stage)

New treatments compared to established treatments in randomized trials (protocol stage)

Newer anticonvulsants in the treatment of anxiety disorders (protocol stage)

Nickel-titanium versus stainless steel instrumentation for orthograde endodontic therapy (protocol stage)

Nicotine vaccines for smoking cessation (protocol stage)

Nitrates for acute heart failure (protocol stage)

Nitrates for chronic heart failure (protocol stage)

Nitrates for stable angina (protocol stage)

Nitric oxide donors for cervical ripening and induction of labour (protocol stage)

Non hormonal interventions for hot flushes in women with a history of breast cancer (protocol stage)

Non-antibiotic therapies for pulmonary infection in cystic fibrosis (protocol stage)

Non-antibiotic treatments for sore throat (protocol stage)

Non-clinical interventions for reducing unnecessary caesarean section (protocol stage)

Non-hormonal therapy for hot flushes in postmenopausal women (protocol stage)

Non-immunosuppressive treatment for IgA nephropathy (protocol stage)

Non-invasive physical treatments for myofascial pain (protocol stage)

Non-invasive ventilation during exercise training for people with chronic obstructive pulmonary disease (protocol stage)

Non-operative treatment for haemorrhoidal disease (protocol stage)

Non-penetrating filtration surgery versus trabeculectomy for open angle glaucoma (protocol stage)

Non-pharmacological interventions for perceptual disorders following stroke and other adult, acquired, non-progressive brain injury (protocol stage)

Non-steroid anti-inflammatory drugs for biliary colics (protocol stage)

Non-surgical interventions for androgenetic alopecia in men (protocol stage)

Non-surgical interventions for convergence insufficiency (protocol stage)

Non-surgical interventions for paediatric pes planus (protocol stage)

Non-surgical management for intussusception in infants and young children (protocol stage)

Nonpharmacological interventions for needle-related procedural pain and post-operative pain in neonates and infants. (protocol stage)

Nonsteroidal anti-inflammatory drugs (NSAIDs) and non-opioids for acute renal colic (protocol stage)

Nonsteroidal anti-inflammatory drugs for assisted reproductive technology (protocol stage)

Notification and support for people exposed to the risk of Creutzfeldt-Jakob disease (CJD) through medical treatment (iatrogenically) (protocol stage)

NSAIDs, analgesics and opioids agents for fibromyalgia syndrome (protocol stage)

Nutritional interventions for liver-transplanted patients (protocol stage)

Nutritional screening for improving professional practice for patient outcomes in hospital and primary care settings (protocol stage)

Nutritional supplementation for glycaemic control in type 2 diabetes mellitus (protocol stage)

Nutritional support for acute kidney injury (protocol stage)

Nutritional support in children and young people with cancer undergoing chemotherapy (protocol stage)

Occupational therapy and physiotherapy for developmental coordination disorder (protocol stage)

Occupational therapy for children with cerebral palsy (protocol stage)

Occupational therapy for cognitive impairment in stroke patients (protocol stage)

Octreotide for the treatment of chylothorax in neonates (protocol stage)

Ocular interventions excluding refraction for reading difficulties in children (protocol stage)

Oestrogens for treatment or prevention of pelvic organ prolapse in women (protocol stage)

Off-pump versus on-pump coronary artery bypass grafting for ischaemic heart disease (protocol stage)

Olanzapine depot for schizophrenia (protocol stage)

Olanzapine versus other atypical antipsychotics for schizophrenia (protocol stage)

Omega-3 fatty acids for autistic spectrum disorder (protocol stage)

Omentoplasty for the prevention of anastomotic leakage after colonic or rectal resection (protocol stage)

One site versus two site phacotrabeculectomy for primary open angle glaucoma (protocol stage)

One-to-one dietary interventions undertaken in a dental setting for a change in dietary behaviour and the prevention of dental caries and erosion (protocol stage)

One-to-one oral hygiene advice provided in a dental setting for oral health (protocol stage)

Open Preperitoneal Techniques versus Lichtenstein Repair for Inguinal Hernia (protocol stage)

Opioid therapy for treating rheumatoid arthritis pain (protocol stage)

Opioids for restless legs syndrome (protocol stage)

Optical aids for visually impaired children (protocol stage)

Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy (protocol stage)

Optimal duration of chemotherapy for advanced non-small cell lung cancer (protocol stage)

Optimal primary surgical treatment for advanced epithelial ovarian cancer (protocol stage)

Optimum force for tooth movement in orthodontic treatment (protocol stage)

Oral adsorbents for preventing or delaying the progression of chronic kidney disease (protocol stage)

Oral and systemic steroids at different doses for acute asthma in hospitalised children (protocol stage)

Oral anti-diabetic agents for women with pre-existing diabetes mellitus/impaired glucose tolerance or previous gestational diabetes mellitus (protocol stage)

Oral anticoagulants for the secondary prevention of coronary heart disease (protocol stage)

Oral antihistamine-decongestant-analgesic combinations for the common cold (protocol stage)

Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts (protocol stage)

Oral baclofen for the management of spasticity in children with cerebral palsy (protocol stage)

Oral budesonide for induction of remission in ulcerative colitis (protocol stage)

Oral contraceptive pill, progestogen or estrogen pre-treatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques (protocol stage)

Oral corticosteroids for induction of remission in ulcerative colitis (protocol stage)

Oral drugs for hypertensive urgencies (protocol stage)

Oral evening primrose oil and borage oil for atopic eczema (protocol stage)

Oral isotretinoin for acne (protocol stage)

Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in premature infants (protocol stage)

Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury (protocol stage)

Oral retinoids for psoriasis (protocol stage)

Oral rinses and mouthwashes for improving outcomes following tonsillectomy (protocol stage)

Oral theophylline for stable asthma in adults (protocol stage)

Oral treatments for toenail onychomycosis (protocol stage)

Oral versus intravenous fluoropyrimidines for metastatic colorectal cancer. (protocol stage)

Orbital radiotherapy for adult thyroid eye disease (protocol stage)

Organic nitrates for prevention of esophageal varices bleeding and rebleeding (protocol stage)

Organisational and professional interventions to promote the uptake of evidence in emergency care: Effects on professional practice and health outcomes (protocol stage)

Organisational travel plans for improving health (protocol stage)

Orlistat for the prevention of cardiovascular diseases in overweight or obese individuals (protocol stage)

Orthodontic treatment for crowded teeth in children (protocol stage)

Orthodontic treatment for prominent lower front teeth in children (protocol stage)

Orthodontics for treating temporomandibular joint (TMJ) disorders (protocol stage)

Orthognathic surgery for surgical correction of patients with mandibular deficiency (protocol stage)

Orthoses for mechanical neck disorders (protocol stage)

Ovarian cyst aspiration prior to in vitro fertilization treatment for subfertility. (protocol stage)

Oxcarbazepine for neuropathic pain (protocol stage)

Oxcarbazepine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability (protocol stage)

Oxygen therapy for acute myocardial infarction (protocol stage)

Oxygen therapy for pneumonia in adults (protocol stage)

Oxygen versus air for nebulising beta-agonist bronchodilators in acute asthma (protocol stage)

Oxytocin versus placebo or no treatment for slow progress in the first stage of spontaneous labour (protocol stage)

Pacifier use versus no pacifier use in breastfeeding term infants for increasing duration of breastfeeding (protocol stage)

Padma 28 for intermittent claudication (protocol stage)

Pain relief for cervical colposcopy treatment (protocol stage)

Pain relief for office gynaecological procedures (protocol stage)

Palivizumab for prophylaxis against respiratory syncytial virus infection in children with cystic fibrosis (protocol stage)

Palliative oxygen for non-hypoxaemic chronic obstructive pulmonary disease (protocol stage)

Palliative surgery versus medical management for bowel obstruction in ovarian cancer (protocol stage)

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine in adults (protocol stage)

Parent mediated reading interventions for children aged birth to 48 months (protocol stage)

Parent training interventions for attention deficit hyperactivity disorder (protocol stage)

Parent training support for intellectually disabled parents (protocol stage)

Parenteral corticosteroids for acute migraine (protocol stage)

Parenteral dihydroergotamine (DHE) for acute migraine (protocol stage)

Parenteral metoclopramide for acute migraine (protocol stage)

Parenteral opioids for maternal pain relief in labour (protocol stage)

Parenteral versus oral iron therapy for adults and children with chronic kidney disease (protocol stage)

Parenting programmes for improving the parenting skills and outcomes for incarcerated parents and their children (protocol stage)

Paroxetine versus other anti-depressive agents for depression (protocol stage)

Pars plana vitrectomy for diabetic macular edema (protocol stage)

Partial breast irradiation for early breast cancer (protocol stage)

Partial exchange transfusion to prevent neurodevelopmental disability in infants with polycythemia (protocol stage)

Particle therapy versus conventional radiotherapy for lung cancer (protocol stage)

Patella resurfacing in total knee arthroplasty (protocol stage)

Patellar taping for patellofemoral pain syndrome in adults (protocol stage)

Patellar tendon versus hamstring autograft for anterior cruciate ligament rupture in adults (protocol stage)

Patient positioning and braces for pain relief and spinal stability in metastatic cord compression in adults (protocol stage)

Paying for performance to improve the delivery of health interventions in low and middle-income countries  (protocol stage)

Peer support strategies for improving the health and well-being of individuals with chronic diseases (protocol stage)

Peer-based interventions for reducing morbidity and mortality in HIV-infected women (protocol stage)

Peginterferon alpha-2a versus peginterferon alpha-2b for chronic hepatitis C (protocol stage)

Peginterferon plus ribavirin versus non-peginterferon plus ribavirin for chronic hepatitis C (protocol stage)

Pegylated interferon for acute hepatitis C (protocol stage)

Pegylated interferon for chronic hepatitis B (protocol stage)

Pegylated liposomal doxorubicin for relapsed ovarian cancer (protocol stage)

Pelvic floor muscle training in combination with another therapy compared with the other therapy alone for urinary incontinence in women (protocol stage)

Pelvic floor muscle training versus other active treatments for urinary incontinence in women (protocol stage)

Pentasaccharides for the prevention of venous thromboembolism (protocol stage)

Pentoxifylline for diabetic kidney disease (protocol stage)

Pentoxifylline for intermittent claudication (protocol stage)

Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances (protocol stage)

Percutaneous technique versus surgical techniques for tracheostomy (protocol stage)

Percutaneous vascular interventions for acute ischaemic stroke (protocol stage)

Percutaneous vertebroplasty for osteoporotic vertebral compression fracture (protocol stage)

Peri-operative antibiotics for hand trauma involving tendons and nerves (protocol stage)

Peri-operative antibiotics for superficial hand trauma (protocol stage)

Perianal injectable bulking agents as treatment for faecal incontinence (protocol stage)

Pericyazine for schizophrenia (protocol stage)

Perineal techniques during the second stage of labour for reducing perineal trauma (protocol stage)

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. (protocol stage)

Perioperative beta-blockers for preventing surgery related mortality and morbidity (protocol stage)

Perioperative buffered versus non-buffered fluid administration for surgery in adults (protocol stage)

Perioperative chemotherapy versus primary surgery for locoregionally advanced resectable adenocarcinoma of the stomach, gastroesophageal junction and lower esophagus (protocol stage)

Perioperative glycaemic control for diabetic patients undergoing surgery (protocol stage)

Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery (protocol stage)

Perioperative intravenous magnesium for preventing atrial fibrillation following coronary artery bypass (protocol stage)

Perioperative nutrition in patients undergoing resection for pancreatic malignancy (protocol stage)

Perioperative prophylactic antibiotics in head and neck cancer surgery (protocol stage)

Perioperative transversus abdominis plane (TAP) blocks for analgesia after abdominal surgery (protocol stage)

Peripheral iridotomy for pigmentary glaucoma (protocol stage)

Peritoneal drainage versus laparotomy as initial surgical treatment for perforated necrotizing enterocolitis in preterm and low birth weight infants (protocol stage)

Pharmaceutical policies: effects on rational drug use, an overview of 13 reviews (protocol stage)

Pharmacologic interventions for treating phantom limb pain (protocol stage)

Pharmacologic therapies for perioperative cerebral protection against neurologic or neurocognitive deficits (protocol stage)

Pharmacologic treatment of depression in multiple sclerosis (protocol stage)

Pharmacological agents for preventing morbidity associated with the haemodynamic response to tracheal intubation (protocol stage)

Pharmacological and non-pharmacological interventions for symptomatic gastroparesis (protocol stage)

Pharmacological anticoagulation and mechanical compression versus mechanical compression alone for venous thromboembolism prophylaxis for post-operative neurosurgical patients (protocol stage)

Pharmacological interventions for antisocial personality disorder (protocol stage)

Pharmacological interventions for essential hypertension in children (protocol stage)

Pharmacological interventions for pain in patients with temporomandibular disorders (TMD) (protocol stage)

Pharmacological interventions for preventing contrast-induced nephropathy (protocol stage)

Pharmacological interventions for preventing salivary gland dysfunction following radiotherapy (protocol stage)

Pharmacological interventions for those who have sexually offended or are at risk of offending (protocol stage)

Pharmacological management for prevention of phantom limb pain after limb amputation (protocol stage)

Pharmacological therapies for maintenance treatments of opium dependency (protocol stage)

Pharmacological therapies for management of opium withdrawal (protocol stage)

Pharmacological therapy for depression in primary brain tumours (protocol stage)

Pharmacological treatment for attention deficit hyperactivity disorder in children with co-morbid tic disorders (protocol stage)

Pharmacological treatments for chronic fatigue syndrome in adults (protocol stage)

Pharmacotherapy for anxiety disorders and comorbid alcohol dependency (protocol stage)

Pharmacotherapy for anxiety disorders in later life (protocol stage)

Pharmacotherapy for hypertension in adults with obstructive sleep apnea (protocol stage)

Pharmacotherapy for preventing and treating alcohol withdrawal seizures (protocol stage)

Pharmacotherapy for prevention of post-traumatic stress disorder (protocol stage)

Pharmacotherapy for sleep bruxism (protocol stage)

Pharmacotherapy for thyroid nodules (protocol stage)

Pharmacotherapy for trichotillomania (protocol stage)

Phosphate binders for preventing and treating bone disease in chronic kidney disease patients (protocol stage)

Phosphodiasterase III inhibitors for chronic asthma (protocol stage)

Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease (protocol stage)

Photodynamic therapy for localised squamous cell carcinoma of the skin and its precursors (protocol stage)

Physical activity and exercise programmes for optimising bone mass in young people (protocol stage)

Physical activity for preventing and treating osteoporosis in men (protocol stage)

Physical examination for lumbar radiculopathy due to disc herniation in patients with low-back pain (protocol stage)

Physical fitness training for people with spinal cord injury (protocol stage)

Physical rehabilitation involving goal setting for older people living in the community (protocol stage)

Physical tests for shoulder impingements and local lesions of bursa, tendon or labrum that may accompany impingement (protocol stage)

Physical therapy for the management of patients with temporomandibular disorders and related pain. (protocol stage)

Physical training for McArdle disease (protocol stage)

Physicopharmacological interventions for reducing propofol-induced pain on induction of anaesthesia in adults (protocol stage)

Physiotherapeutic mechanisms for prevention of deep vein thrombosis in patients at risk of haemorrhage (protocol stage)

Physiotherapy and physiotherapeutical modalities for lateral epicondylitis (protocol stage)

Phytoestrogens in the treatment of postmenopausal osteoporosis (protocol stage)

Piribedil for levodopa-induced complications in Parkinson's disease (protocol stage)

Piribedil for symptomatic management of Parkinson's disease (protocol stage)

Piribedil versus levodopa in early Parkinson's disease (protocol stage)

Planned caesarean section for women with a twin pregnancy (protocol stage)

Planned early birth versus expectant management for women with preterm prelabour rupture of membranes prior to 37 weeks' gestation for improving pregnancy outcome (protocol stage)

Planned home versus hospital care for preterm prelabour rupture of the membranes (PPROM) prior to 37 weeks' gestation (protocol stage)

Plasmakinetic resection versus transurethral resection of the prostate for benign prostatic hyperplasia (protocol stage)

Plating versus intramedullary nailing for humeral shaft fractures in adults (protocol stage)

Pneumococcal vaccine for prevention of Streptococcus pneumoniae infection in HIV infected persons. (protocol stage)

Pneumococcal vaccines for prevention of Streptococcus pneumoniae disease in patients undergoing chemotherapy and/or radiotherapy (protocol stage)

Polyclonal and monoclonal antibodies for induction therapy in kidney transplant recipients (protocol stage)

Polyethylene glycol for chronic constipation in adults (protocol stage)

Polyunsaturated fatty acids (PUFAs) for attention deficit hyperactivity disorder in children and adolescents (protocol stage)

Posatirelin (l-pyro-2-aminoadipyl-l-leucyl-l-prolinamide) treatment for persons with dementia (protocol stage)

Position in the second stage of labour for women with epidural anaesthesia (protocol stage)

Positive end-expiratory pressure (PEEP) during anaesthesia for the prevention of mortality and postoperative pulmonary complications (protocol stage)

Positive end-expiratory pressure for infants requiring conventional mechanical ventilation for hyaline membrane disease or bronchopulmonary dysplasia (protocol stage)

Post-acute physiotherapy for primary total hip arthroplasty (protocol stage)

Post-acute physiotherapy for primary total knee arthroplasty (protocol stage)

Postoperative adjuvant chemotherapy in rectal cancer operated for cure. (protocol stage)

Postoperative chemoradiation for head and neck cancers (protocol stage)

Postoperative tamoxifen for ductal carcinoma in situ (protocol stage)

Powered toothbrushes for oral health (protocol stage)

Pre-hospital emergency pathways for people with suspected stroke (protocol stage)

Preconception care for diabetic women to improve maternal and infant health (protocol stage)

Premedication for endotracheal intubation in neonates (protocol stage)

Preoperative nutrition to prevent post operative complications in malnourished patients undergoing elective abdominal surgery (protocol stage)

Preoperative radiotherapy chemotherapy and surgery versus surgery alone for esophageal cancer (protocol stage)

Preoperative ripening of the cervix before operative hysteroscopy (protocol stage)

Preoperative vascular access evaluation for haemodialysis patients (protocol stage)

Preoxygenation for tracheal suctioning in ventilated adults (protocol stage)

Prescribed hypocaloric nutrition support for critically ill adults (protocol stage)

Pressure garment therapy after burn injury (protocol stage)

Pressure relieving devices for preventing heel pressure ulcers (protocol stage)

Pressure relieving devices for treating heel pressure ulcers (protocol stage)

Pressure support versus T tube for weaning from mechanical ventilation in adults (protocol stage)

Pressurised-metered dose inhalers versus other hand-held inhalation devices for the delivery of inhaled corticosteroid therapy in children with non-acute asthma (protocol stage)

Pressurised-metred does inhalers versus hand-held inhalers for the delivery of corticosteroids in adults with asthma (protocol stage)

Preterm formula milk versus term formula milk for feeding preterm or low birth weight infants (protocol stage)

Prevention and treatment interventions for nausea and vomiting during initiation of chronic opioid therapy (protocol stage)

Prevention of percutaneous injuries with risk of hepatitis B, hepatitis C, or other viral infections for health-care workers (protocol stage)

Prevention of suicide and suicidal behaviour in adolescents (protocol stage)

Prevention of venous insufficiency in a standing workers population (protocol stage)

Preventive staff-support interventions for health workers (protocol stage)

Primaquine for reducing transmission of Plasmodium falciparum malaria (protocol stage)

Primary and community health care professionals in hospital emergency departments: effects on process and outcome of care and resources (protocol stage)

Primary immunosuppression following heart transplantation (protocol stage)

Primary prevention interventions for reducing school violence (protocol stage)

Primary stenting versus balloon angioplasty for stenotic and occlusive lesions of the iliac artery. (protocol stage)

Primary surgery versus primary radiation therapy with or without chemotherapy for early adenocarcinoma of the uterine cervix (protocol stage)

Probiotic agents for the treatment of diarrhoea-predominant irritable bowel syndrome (protocol stage)

Probiotics for maintenance of remission in ulcerative colitis (protocol stage)

Probiotics for preventing acute upper respiratory tract infections (protocol stage)

Probiotics for the prevention of Clostridium difficile associated diarrhea in adults and children (protocol stage)

Probiotics for treating persistent diarrhoea in children (protocol stage)

Problem solving treatment (PST) for emotional problems in primary care (protocol stage)

Probucol for type 2 diabetes mellitus (protocol stage)

Procalcitonin to initiate or withhold antibiotics in acute respiratory tract infections (protocol stage)

Professional interventions for general practitioners on the management of musculoskeletal conditions (protocol stage)

Progestational agents for treating threatened or established preterm labour (protocol stage)

Progestin-only pills for contraception (protocol stage)

Prokinetic drugs for the treatment of constipation - predominant irritable bowel syndrome (protocol stage)

Promoting patient uptake and adherence in cardiac rehabilitation (protocol stage)

Prone position for acute respiratory failure in adults (protocol stage)

Prophylactic antibiotics to reduce morbidity and mortality in newborn infants with intercostal catheters (protocol stage)

Prophylactic chemotherapy for hydatidiform mole (protocol stage)

Prophylactic corticosteroids for cardiopulmonary bypass in adults (protocol stage)

Prophylactic drug management for febrile seizures in children (protocol stage)

Prophylactic nasal intermittent positive pressure ventilation (NIPPV) versus prophylactic nasal continuous positive airway pressure (NCPAP) for preterm infants (protocol stage)

Prophylactic non-steroidal anti-inflammatory agents for the prevention of cystoid macular oedema after cataract surgery (protocol stage)

Prophylactic phototherapy for preventing jaundice in preterm very low birth weight infants (protocol stage)

Prophylaxis for stress-related gastrointestinal bleeding (protocol stage)

Propofol for procedural sedation/anesthesia in neonates (protocol stage)

Prostaglandin E1 analogues for chronic hepatitis B (protocol stage)

Prostaglandin E1 for diabetic neuropathy (protocol stage)

Prostaglandin E1 for preventing the progression of diabetic kidney disease (protocol stage)

Prostaglandins for adult liver transplanted patients (protocol stage)

Prostanoids for critical limb ischemia (protocol stage)

Protease modulating dressings for treating diabetic foot ulcers (protocol stage)

Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients (protocol stage)

Provider training and experience for people living with HIV/AIDS (protocol stage)

Provision of a surgeon's performance data for people considering elective surgery (protocol stage)

Psychoanalytic/psychodynamic psychotherapy for children and adolescents who have been sexually abused (protocol stage)

Psychological and pharmacological interventions for depression in patients with coronary artery disease (protocol stage)

Psychological interventions for antisocial personality disorder (protocol stage)

Psychological interventions for reducing dental anxiety in children (protocol stage)

Psychological interventions for reducing postoperative morbidity in dental surgery in adults (protocol stage)

Psychological interventions for those who have sexually offended or are at risk of offending (protocol stage)

Psychological interventions for treatment of inflammatory bowel disease (protocol stage)

Psychological therapies for the prevention and treatment of post-traumatic stress disorder in children and adolescents (protocol stage)

Psychological therapies versus pharmacotherapy for obsessive compulsive disorder (protocol stage)

Psychologically mediated effects of the physical healthcare environment on work-related outcomes of healthcare personnel (protocol stage)

Psychosocial interventions for alcohol use disorders (protocol stage)

Psychosocial interventions for prevention of depression in older people (protocol stage)

Psychosocial interventions for the maintenance of weight loss in obese adults (protocol stage)

Psychosocial interventions for the reduction of injection and sexual risk behaviour for preventing HIV in drug users (protocol stage)

Psychosocial interventions for the secondary prevention of mental health problems in people who have sustained a traumatic physical injury (protocol stage)

Psychosocial interventions to improve quality of life and emotional wellbeing for recently diagnosed cancer patients (protocol stage)

Psychotherapy for depression in children and adolescents (protocol stage)

Punctal occlusion for dry eye syndrome (protocol stage)

Push versus gravity for intermittent bolus gavage tube feeding of premature and low birth weight infants (protocol stage)

Pyronaridine for treating uncomplicated falciparum malaria (protocol stage)

Quetiapine versus other atypical antipsychotics for schizophrenia (protocol stage)

Quetiapine versus typical antipsychotic medications for schizophrenia (protocol stage)

Quinine for muscle cramps (protocol stage)

Radical Prostatectomy versus Watchful Waiting for Prostate Cancer (protocol stage)

Radiofrequency ablation in the treatment of isolated liver metastases from colorectal cancer (protocol stage)

Radiotherapy for gastric cancer (protocol stage)

Radiotherapy versus combined modality therapy for anal carcinoma (protocol stage)

Rapid HIV tests and counseling for pregnant women for preventing mother-to-child HIV transmission (protocol stage)

Rasagiline for levodopa-induced motor complications in Parkinson´s disease (protocol stage)

Re-positioning for pressure ulcer prevention (protocol stage)

Reboxetine versus other antidepressive agents for depression (protocol stage)

Recombinant growth hormone in Prader-Willi Syndrome (protocol stage)

Recombinant human insulin-like growth factor I for acute kidney injury (protocol stage)

Recombinant human interleukin 10 for induction of remission in Crohn's disease (protocol stage)

Recombinant versus urinary derived gonadotrophins for ovarian stimulation in in vitro fertilisation and intra-cytoplasmic sperm injection cycles (protocol stage)

Rectal 5-aminosalicylic acid for induction of remission in ulcerative colitis (protocol stage)

Rectal 5-aminosalicylic acid for maintenance of remission in ulcerative colitis (protocol stage)

Rectal analgesia for pain relief after caesarean section (protocol stage)

Rectal corticosteroids for induction of remission in ulcerative colitis (protocol stage)

Rectal corticosteroids for maintenance of remission in ulcerative colitis (protocol stage)

Reduction versus abrupt cessation in smokers who want to quit. (protocol stage)

Reflexology for treatment of constipation (protocol stage)

Regular fixed-dose treatment with formoterol and inhaled corticosteroids versus regular treatment with salmeterol and inhaled corticosteroids for chronic asthma: serious adverse events (protocol stage)

Rehabilitation after surgery for Dupuytren's Contracture (protocol stage)

Rehabilitation interventions for improving physical and psychosocial functioning after hip fracture in older people (protocol stage)

Rehabilitation programmes for schizophrenia (protocol stage)

Rehabilitation treatments following carpal tunnel surgery (protocol stage)

Reiki treatment for psychological symptoms (protocol stage)

Relaxation therapy for preventing and treating preterm labour (protocol stage)

Remediating buildings damaged by dampness and mould for preventing respiratory tract symptoms, infections and asthma (protocol stage)

Remifentanil for analgesia and sedation of critically ill patients in intensive care units (protocol stage)

Renal replacement therapy for preventing contrast-induced nephropathy (protocol stage)

Repeat digital cervical assessment in pregnancy for identifying women at risk of preterm labour (protocol stage)

Repeated use of pre- and postcoital hormonal contraception for prevention of pregnancy (protocol stage)

Replacement versus repair of defective restorations in adults: amalgam (protocol stage)

Replacement versus repair of defective restorations in adults: resin composite (protocol stage)

Respiratory muscle training in children and adults with neuromuscular disease (protocol stage)

Restricting oral fluid and food intake during labour (protocol stage)

Retroperitoneal drainage versus no drainage after pelvic lymphadenectomy for the prevention of lymphocyst formation in patients with gynaecological malignancies (protocol stage)

Return to work interventions for adjustment disorders (protocol stage)

Rheum officinale (a Chinese medicinal herb) for chronic kidney disease (protocol stage)

Rhythm control versus rate control for atrial fibrillation/flutter (protocol stage)

Riboflavin (vitamin B2) for the prevention of migraine (protocol stage)

Rigid versus wire fixation following jaw surgery for developmental dentofacial deformity (protocol stage)

Risk scoring for the primary prevention of cardiovascular disease (protocol stage)

Risk scoring systems for predicting preterm birth with the aim of reducing associated adverse outcomes (protocol stage)

Risperidone versus other atypical antipsychotics for schizophrenia (protocol stage)

Risperidone versus placebo for schizophrenia (protocol stage)

Ritonavir-boosted protease inhibitor-containing regimens versus non-boosted protease-inhibitor-containing regimens for reducing morbidity and mortality in people with HIV/AIDS (protocol stage)

Rituximab for rheumatoid arthritis (protocol stage)

Roselle for hypertension in adults (protocol stage)

Routine screening by echocardiography to reduce morbidity and mortality from congenital heart disease in neonates with Down syndrome (protocol stage)

Routine vitamin A supplementation for the prevention of blindness due to measles infection in children (protocol stage)

Routine vs. voluntary HIV testing for increasing HIV testing rates (protocol stage)

Rutosides for prevention of post thrombotic syndrome (protocol stage)

Rutosides for treatment of post-thrombotic syndrome (protocol stage)

Saline nasal irrigation for acute upper respiratory tract infections (protocol stage)

Salt fluoridation for preventing dental caries (protocol stage)

Sapropterin dihydrochloride for phenylketonuria (protocol stage)

Sarpogrelate for peripheral arterial disease (protocol stage)

Scalpel versus electrosurgery for abdominal incisions (protocol stage)

School-based interventions to postpone sexual intercourse and promote condom use among adolescents (protocol stage)

Screening for gestational diabetes mellitus for improving maternal and infant health (protocol stage)

Screening for oesophageal cancer (protocol stage)

Screening for testicular cancer (protocol stage)

Screening for type 2 diabetes mellitus (protocol stage)

Screening programmes for developmental dysplasia of the hip in newborn infants (protocol stage)

Screening sigmoidoscopy and colonoscopy for reducing colorectal cancer mortality in asymtomatic persons (protocol stage)

Screening women for intimate partner violence in health care settings (protocol stage)

Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE (protocol stage)

Search strategies to identify reports of randomized trials in MEDLINE (protocol stage)

Second generation dihydropyridine calcium channel blockers for heart failure (protocol stage)

Second-generation antipsychotic drugs for anxiety disorders (protocol stage)

Second-generation antipsychotic drugs for major depressive disorder (protocol stage)

Second-generation antipsychotic drugs for obsessive compulsive disorder (protocol stage)

Second-line chemotherapy for locally advanced or metastatic small cell lung cancer (protocol stage)

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate (protocol stage)

Sedative techniques for endoscopic retrograde cholangiopancreatography (protocol stage)

Selective cyclooxygenase 2 inhibitors for the treatment of rheumatological manifestations of inflammatory bowel disease (protocol stage)

Selective dorsal rhizotomy in the management of children with spastic cerebral palsy (protocol stage)

Selective serotonin reuptake inhibitors for the treatment of alcohol use disorders (protocol stage)

Selective serotonin reuptake inhibitors for the treatment of autism spectrum disorders (protocol stage)

Selegiline compared to other agents for levodopa-induced motor complications in Parkinson's disease (protocol stage)

Selegiline for levodopa-induced motor complications in Parkinson's disease (protocol stage)

Selenium for preventing cancer (protocol stage)

Self-ligating orthodontic braces for straightening teeth (protocol stage)

Self-management education for cystic fibrosis (protocol stage)

Self-management programme for ankylosing spondylitis (protocol stage)

Self-monitoring and self-management of oral anticoagulation (protocol stage)

Semi-recumbent position versus supine position for the prevention of ventilator associated pneumonia in adults requiring mechanical ventilation (protocol stage)

Sensory environment on health-related outcomes of hospital patients (protocol stage)

Sentinel node biopsy for diagnosis of pelvic lymph node involvement in early stage cervical cancer (protocol stage)

Separate care for new mother and infant versus rooming-in for increasing the duration of breastfeeding (protocol stage)

Serotonin receptor antagonists for highly emetogenic chemotherapy in adults (protocol stage)

Service organisation for the secondary prevention of ischaemic heart disease (protocol stage)

Sevoflurane versus other general anaesthesia on postoperative behaviour disturbance in children (protocol stage)

Shared decision making interventions for people with mental health conditions (protocol stage)

Short course versus long course intravenous therapy of the same antibiotic for severe community-acquired pneumonia in children aged two months to 59 months (protocol stage)

Short course versus prolonged course antibiotic therapy for hospital-acquired pneumonia in critically ill adults (protocol stage)

Simple dilatation, endoscopic urethrotomy, and urethroplasty for urethral stricture in adults (protocol stage)

Simultaneous bilateral training for improving arm function after stroke (protocol stage)

Singing for children and adults with bronchiectasis (protocol stage)

Singing for children and adults with cystic fibrosis (protocol stage)

Single dose oral codeine, as a single agent, for acute postoperative pain in adults (protocol stage)

Single dose oral diflunisal for acute postoperative pain in adults (protocol stage)

Single dose oral fenoprofen for acute postoperative pain in adults (protocol stage)

Single dose oral mefenamic acid for acute postoperative pain in adults (protocol stage)

Single dose propacetamol or IV paracetamol for postoperative pain (protocol stage)

Single versus multiple inhalers for the administration of corticosteroid and long-acting beta-agonists in chronic asthma (protocol stage)

Skin preparation for preventing infection following caesarean section (protocol stage)

Slow versus fast subcutaneous heparin injections for prevention of bruising and site-pain intensity (protocol stage)

Smoking cessation interventions for smokers with current or past depression (protocol stage)

Social and lifestyle interventions for preventing low birthweight in South Asians (protocol stage)

Sodium ferulate for preventing the progression of diabetic kidney disease (protocol stage)

Sound therapy (masking) in the management of tinnitus in adults (protocol stage)

Specialised antenatal clinics for women with a pregnancy at high risk of preterm birth (excluding multiple pregnancy) to improve maternal and infant outcomes (protocol stage)

Specialty teams for neonatal transport to neonatal intensive care units for prevention of morbidity and mortality (protocol stage)

Spectacle correction versus no spectacles for prevention of strabismus in hyperopic children (protocol stage)

Spinal manipulative therapy for chronic low-back pain (protocol stage)

Spiritual and religious interventions for adults in the terminal phase of disease (protocol stage)

Spironolactone for hypertension (protocol stage)

Sports, games and play-based interventions for post-traumatic stress disorder (PTSD) (protocol stage)

Stage-based interventions for smoking cessation (protocol stage)

Staples versus sutures for closing leg wounds after vein graft harvesting for coronary artery bypass surgery. (protocol stage)

Statins for acute coronary syndrome (protocol stage)

Statins for acute ischemic stroke (protocol stage)

Statins for children with familial hypercholesterolemia (protocol stage)

Statins for dyslipidemia in HIV/AIDS patients on antiretrovirals (protocol stage)

Statins for osteoporosis in postmenopausal women (protocol stage)

Statins for preventing major vascular events in people with hypertension (protocol stage)

Statins for the primary prevention of cardiovascular disease (protocol stage)

Statins for the treatment of Alzheimer's disease and dementia (protocol stage)

Steam inhalation or humidified oxygen for acute bronchiolitis in children up to three years of age (protocol stage)

Stem cell therapy for ischaemic heart disease and congestive heart failure (protocol stage)

Stem cell transplantation for acute myelocytic leukaemia in paediatric patients in first remission (protocol stage)

Stem cell transplantation for ischemic stroke (protocol stage)

Steroid avoidance or withdrawal for pancreas and kidney transplant recipients (protocol stage)

Steroid hormone treatment for Kawasaki disease in children (protocol stage)

Steroid sparing drug treatments for giant cell arteritis (protocol stage)

Steroid sparing drug treatments for polymyalgia rheumatica (protocol stage)

Steroids versus Immunoglobulin for Pediatric Acute Idiopathic Thrombocytopenic Purpura (protocol stage)

Stimulant drugs for narcolepsy in adults (protocol stage)