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Chinese herbal medicines in the treatment of ectopic pregnancyDengfeng W, Lina H, Marjoribanks J, Haijun J, Ying S, Zhang J, Liu GJ, Wu T
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SummaryChinese herbal medicine (CHM) in the treatment of ectopic pregnancy.Ectopic pregnancy is the leading cause of pregnancy-related deaths in the first trimester of pregnancy. Its incidence has increased to between one and two percent of pregnancies. Chinese herbal medicines have been used to treat this condition in China and other countries. The review authors investigated 166 studies that claimed to be randomised controlled trials and that used traditional Chinese herbal medicines in the treatment of ectopic pregnancy. Only two of these studies were confirmed to be randomised controlled trials. Both trials were of poor quality in terms of design and how they were conducted. These studies did not provide clear evidence that CHM is beneficial in the treatment of ectopic pregnancy.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2010 Issue 1, Copyright © 2010 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
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October 17. 2007 AbstractBackgroundTraditional Chinese herbal medicine (CHM) has been used widely in Chinese hospitals to treat ectopic pregnancy. Many studies have been published supporting its use but the evidence has not been systematically reviewed. ObjectivesTo determine the effectiveness and safety of CHM in the treatment of ectopic pregnancy. Search strategyComputerised databases (CENTRAL (The Cochrane Library), MEDLINE, EMBASE, Chinese Biomedical Database, China National Knowledge Infrastructure, VIP, Traditional Chinese Medicine Database System) were searched from their inception to March 2006 for relevant trials. Selection criteriaRandomised controlled trials (RCT) on the use of CHM for the treatment of ectopic pregnancy. Data collection and analysisOriginal authors of the identified studies were contacted to determine the trial design and identify authentic RCTs. Two review authors extracted and analysed the data. Main resultsThe search identified 166 trials. Only two studies involving a total of 157 participants were confirmed to be authentic RCTs ( Li 2004c; Zhao 2000). Both were of poor methodological quality with a high risk of conflicted interest and potential for bias in favour of the intervention. We could not reach a definitive conclusion from the results. The pooled result showed that adding a Western medicine to CHM resulted in a significantly higher treatment success rate than with CHM alone (RR 1.33, 95% CI 1.08 to 1.63). When CHM plus Western medicine was compared to CHM alone for the time to disappearance of abdominal pain, again the results favoured the arm that included Western medicine (RR -2.09, 95% CI -4.14 to -0.04). Results were inconsistent for the time required for human chorionic gonadotropin (beta-hCG) to return to normal. One study favoured CHM plus Western medicine over Western medicine (with or without placebo) (WMD -6.68, 95% CI -11.49 to -1.87); when CHM plus Western medicine was compared to CHM alone the results favoured the arm that included Western medicine (WMD -8.12, 95% CI -10.89 to -5.53). Authors' conclusionsWe have not found any well-designed trials investigating traditional Chinese herbal medicines in the treatment of ectopic pregnancy. We cannot support or refute any CHM preparation for clinical use on the basis of evidence from randomised controlled trials. |