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Non-pharmacological interventions for epilepsy in people with intellectual disabilitiesBeavis J, Kerr M, Marson AG
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SummaryNon-pharmacological interventions for epilepsy in people with intellectual disabilitiesThis review identified the lack of any randomised controlled trials (RCTs) for non-pharmacological interventions in people with epilepsy and intellectual disabilities. There is evidently a need for well-designed RCTs to ascertain the effects of non-pharmacological interventions on seizure and behavioural outcomes in this population, however, good quality RCT evidence in the non-intellectually disabled should be assessed for their side effect and efficacy profile prior to such an undertaking.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2010 Issue 1, Copyright © 2010 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
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October 17. 2007 AbstractBackgroundApproximately 30% of epilepsy patients remain refractory to drug treatment and continue to experience seizures whilst taking one or more antiepileptic drugs. There are a number of non-pharmacological interventions available to refractory patients which may be used in conjunction with or as an alternative to antiepileptic medication. In view of the fact that seizures in intellectually disabled people are often complex and refractory to pharmacological interventions it is evident that good quality randomised controlled trials (RCTs) assessing the efficacy of alternatives or adjuncts to pharmacological interventions are needed in this population. ObjectivesThe aim of our study was to assess the data available from randomised controlled trials of non-pharmacological interventions in patients with epilepsy and intellectual disabilities. Search strategyWe searched The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 4, 2006), MEDLINE (Ovid, 1966 to October 2006) and PsycInfo (Ovid, 1806 to October 2006). Selection criteriaRandomised controlled trials of non-pharmacological interventions for people with epilepsy and intellectual disabilities Data collection and analysisTwo review authors independently applied inclusion criteria and extracted data. Main resultsNo RCTs were found for this study population. Authors' conclusionsThis review has highlighted the need for well-designed randomised controlled trials to assess the effect of non-pharmacological interventions on seizure and behavioural outcomes in an intellectually disabled epilepsy population. |