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Topical corticosteroids as adjunctive therapy for bacterial keratitisSuwan-apichon O, Reyes JMG, Herretes S, Vedula SS, Chuck RS
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SummaryTopical corticosteroids as adjunctive therapy for bacterial keratitisBacterial keratitis or corneal inflammation due to bacterial infection, is a potentially sight threatening condition. Risk factors for bacterial keratitis, a serious ocular condition that can result in visual disability, include contact lens wear, ocular surface disease, corneal trauma and previous ocular or eyelid surgery. Topical antibiotics are the mainstay of treatment for bacterial keratitis. The usefulness of adjunct treatment with topical corticosteroids is controversial. We identified a single randomized trial of borderline methodological quality, evaluating adjunct corticosteroid therapy for bacterial keratitis. We do not have sufficient evidence to determine the effects of adjunct treatment with topical corticosteroids for bacterial keratitis.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2010 Issue 1, Copyright © 2010 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
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October 17. 2007 AbstractBackgroundBacterial keratitis is a serious ocular infectious disease that can lead to severe visual disability. Risk factors for bacterial corneal infection include contact lens wear, ocular surface disease, corneal trauma and previous ocular or eyelid surgery. Topical antibiotics constitute the mainstay of treatment in cases of bacterial keratitis where as the use of topical corticosteroids remains controversial. Topical corticosteroids are usually used to control inflammation using the smallest amount of the drug. Their use requires optimal timing, concomitant antibiotics and careful follow up. ObjectivesThe objective of the review was to assess the clinical effectiveness and adverse effects of corticosteroids as adjunctive therapy for bacterial keratitis. Search strategyWe searched CENTRAL, MEDLINE, EMBASE, and LILACS up to 15 January 2007. We also searched the Science Citation Index to identify additional studies that had cited the included trial, an online database of ongoing trials (www.clinicaltrials.gov), reference lists of included trials, earlier reviews and the American Academy of Ophthalmology guidelines. We also contacted experts to identify any unpublished and ongoing randomized trials. Selection criteriaWe included randomized controlled trials evaluating adjunctive therapy with topical corticosteroids in people with bacterial keratitis. Data collection and analysisTwo review authors independently screened all the retrieved articles. Methodological quality of the one included trial was assessed using forms developed using pre-specified criteria by at least two review authors. We planned to extract data on outcomes using forms developed for the purpose. We planned to report risk ratios for dichotomous outcomes and mean differences for continuous outcomes. Main resultsA single trial was eligible for inclusion in the review. Participants in the trial were randomized using a random numbers table. Allocation concealment was not attempted. Masking of participants, and care-providers was also not attempted. Outcome assessment was conducted independently by two physicians. Neither was masked to the treatment allocation. The trial reported the healing rate of epithelial defects and improvement in visual acuity. Authors' conclusionsThere are no good quality randomized trials evaluating the effects of adjunct use of topical corticosteroids in bacterial keratitis. The only randomized trial we identified in the literature suffered from major methodological inadequacies. |