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Yizhi capsule for vascular dementiaWu T, Qingpu L, Zhenyong Y
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SummaryThere is no evidence from randomised controlled trials for or against the use of 'Yizhi capsule' as a treatment for vascular dementiaVascular dementia (VD) is a syndrome or diagnosis that has different causes and clinical manifestations relating to several different vascular mechanisms and changes in the brain. It influences a patient's quality of life seriously. 'Yizhi capsule' is believed to be effective in the treatment of vascular dementia for improving cognitive function. The review authors found no randomised placebo controlled trials that considered 'Yizhi capsule' for patients with vascular dementia. High quality, placebo controlled research is needed.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2010 Issue 1, Copyright © 2010 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
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April 18. 2007 AbstractBackgroundVascular dementia (VD) is a syndrome or diagnosis that has different causes and clinical manifestations relating to several different vascular mechanisms and changes in the brain. Some traditional Chinese herbal medicines were developed for treating VD. Yizhi capsule is one such herbal concoction which is reported to improve clinical symptoms significantly. The efficacy and adverse effects of Yizhi capsule need to be reviewed systematically and assessed critically to inform clinical practice and guide the continued search for new treatment regimens. ObjectivesTo assess the effectiveness and possible adverse events of 'Yizhi capsule' in treating vascular dementia. Search strategyThe Cochrane Dementia and Cognitive Improvement Group's Specialised Register, The Cochrane Library, EMBASE, MEDLINE, PsycINFO, CONAHL, LILACS, clinical trial registries and grey literature sources were searched on 8 January 2009 using the terms yi-zhi, "yi zhi" and yizhi. In addition the review authors searched a variety of Chinese databases. Selection criteriaRandomised, placebo controlled trials in which patients with vascular dementia were treated with 'Yizhi capsule' were included. Data collection and analysisTwo authors independently assessed trial quality and extracted data. We telephoned study authors for missing information as to whether treatment allocation was randomised and other methodological details. Main resultsNo studies were found that met the inclusion criteria. We identified nine references to trials which included the term 'Yizhi capsule' in the description of the interventions. Two study authors were contacted by telephone and we discovered that the allocation methods they had used were not actually randomised. Four references were describing the same study. Three studies were excluded because 'positive drugs' were used as a control. Authors' conclusionsThere is no evidence from randomised controlled trials to support or proscribe against the use of 'Yizhi capsule' as a treatment for vascular dementia. |