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Zhiling decoction for vascular dementiaJirong Y, Yang X, Wu T, Defen S, Dong B
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SummaryNo evidence from randomised controlled trials for or against the use of Zhiling concoction in the treatment of people with vascular dementiaZhiling is a decoction of 15 Chinese herbs which is thought to contribute to dilating cerebral vessels and increasing cerebral blood flow, as well as reducing serum cholesterol. No randomised controlled trials of Zhiling decoction versus placebo were found and thus its efficacy and safety could not be analysed in this review. There is a need for randomised placebo controlled trials of Zhiling decoction.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2008 Issue 3, Copyright © 2008 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
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October 18. 2004 AbstractBackgroundZhiling decoction has a fixed composition of 15 Chinese herbs. The properties of each of these herbs and in combination provide the therapeutic rationale for a possible action of Zhiling decoction in dilating cerebral vessels and increasing cerebral blood flow, as well as reducing serum cholesterol. Thus the aim of this review is to evaluate efficacy and safety of Zhiling decoction for the treatment of vascular dementia. ObjectivesTo assess the efficacy and safety of Zhiling decoction for vascular dementia. Search strategyThe Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG), The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL and LILACS were searched on 17 March 2008 using the term: zhiling. The CDCIG Specialized Register contains records from all major health care databases (The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL, LILACS) as well as from many trials databases and grey literature sources. Selection criteriaRandomised trials comparing Zhiling decoction with placebo in people with vascular dementia. Data collection and analysisTwo reviewers independently assessed trial quality and extracted data. Study authors were contacted for additional information. Adverse effects information was collected from the trials where possible. Main resultsIn the absence of any suitable randomised placebo-controlled trials in this area, we were unable to perform a meta-analysis. Authors' conclusionsThe currently available evidence is insufficient to assess the potential for Zhiling decoction in the treatment of vascular dementia. The little objective data concerning the management of Zhiling decoction versus Naofukang suggests that Zhiling decoction may be effective in treating vascular dementia. |