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Prophylactic antibiotics to reduce morbidity and mortality in ventilated newborn infantsInglis GDT, Jardine LA, Davies MW
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SummaryProphylactic antibiotics to reduce morbidity and mortality in ventilated newborn infantsThere is insufficient evidence from randomised trials to either support or refute the routine use of preventive antibiotics in newborn babies with breathing tubes in place. Newborn babies occasionally require a tube in the windpipe to help them breathe. The use of a breathing may cause the baby to develop an infection and become sick. Some people believe that antibiotics should be given to all babies with breathing tubes in order to reduce the chance of an infection occurring. However, antibiotics can have unwanted effects. It is possible that these effects might be worse than any benefit gained. The reviewers found insufficient evidence to either support or refute the routine use of antibiotics for all babies with breathing tubes.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2010 Issue 1, Copyright © 2010 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
This version first published online:
January 26. 2004 AbstractBackgroundIntubation is associated with bacterial colonisation of the respiratory tract and, therefore, may increase the risk of acquiring an infection. The infection may prolong the need for mechanical ventilation and increase the risk of chronic lung disease. The use of prophylactic antibiotics has been advocated for all mechanically ventilated newborns in order to reduce the risk of colonisation and the acquisition of infection. However, there is the possibility that the harm this may cause might outweigh the benefit. ObjectivesTo assess the effects of prophylactic antibiotics on mortality and morbidity in intubated, ventilated newborn infants who are not known to have infection. In separate comparisons, two different policies regarding the prophylactic use of antibiotics in intubated, ventilated infants were reviewed: Search strategyMEDLINE (January 1950 to March 2007), CINAHL (1982 to March 2007), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2007), the Cochrane Neonatal Group Specialised Register and reference lists of articles were searched. Selection criteriaRandomised controlled trials of sufficient quality in which mechanically ventilated newborn infants are randomised to receive prophylactic antibiotics versus placebo or no treatment. Data collection and analysisTwo reviewers independently assessed trial quality. Main resultsTwo studies met the criteria for inclusion in this review. One was of insufficient quality to draw any meaningful conclusions. The other was of fair quality and found no significant differences between treatment and control groups in any of the reported outcomes, however, the rates of septicaemia were not reported. Authors' conclusionsThere is insufficient evidence from randomised trials to support or refute the use of prophylactic antibiotics when starting mechanical ventilation in newborn infants, or to support or refute continuing antibiotics once initial cultures have ruled out infection in mechanically ventilated newborn infants. |