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Heparin for pregnant women with acquired or inherited thrombophiliasWalker MC, Ferguson SE, Allen VM
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SummaryHeparin for pregnant women with acquired or inherited thrombophiliasNo evidence from trials on the effects of heparin on pregnancy outcomes for women with a thrombophilia. Thrombophilias are a group of disorders where the person's blood is prone to thrombosis (clotting). These blood clots can cause life-threatening complications such as DVT (deep vein thrombosis). Thrombophilia can cause a number of serious complications in pregnancy, such as growth restriction, stillbirth and severe pre-eclampsia. Heparin is an anti-clotting drug which thins the blood. It does not seem to have adverse effects on the baby during pregnancy, and few adverse effects on the pregnant woman. However, the review found no trials on the effects of heparin on pregnancy outcomes for women with a thrombophilia.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2009 Issue 4, Copyright © 2009 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
This version first published online:
April 22. 2003 AbstractBackgroundThrombophilias, which are associated with a predisposition to thrombotic events, have been implicated in adverse obstetrical outcomes such as intrauterine growth restriction, stillbirth, severe early onset pre-eclampsia, and placental abruption. Heparin administration in pregnancy may reduce the risk of these events. ObjectivesThe objective of this review was to assess the effects of heparin on pregnancy outcomes for women with a thrombophilia. Search strategyWe searched the Cochrane Pregnancy and Childbirth Group trials register (July 2002), MEDLINE, EMBASE, CINAHL, Scidex (via OVID Technologies - July 2002) and reference lists and personal files. Selection criteriaRandomized controlled trials comparing heparin with placebo or no treatment, or randomized controlled trials comparing any two treatments. Quasi randomized studies would be included. Data collection and analysisData would be abstracted from identified studies and recorded on a paper form by two reviewers. Main resultsNo studies were included. Authors' conclusionsThere are no completed trials to determine the effects of heparin on pregnancy outcomes for women with a thrombophilia. |