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Pneumococcal vaccine for asthmaSheikh A, Alves B, Dhami S
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SummaryPneumococcal vaccine for asthmaPneumonia is a serious illness for people who have asthma and pneumococcal vaccine has been studied to see if it reduces illness or death in those people. A thorough search for randomised controlled trials of pneumococcal vaccine in asthma has found only one small study in children which was not of high quality. This showed a reduction in the rate of asthma attacks from ten per year to seven per year. Randomised trials to test pneumococcal vaccine in asthmatic children and adults are needed to assess how beneficial it is for asthmatics to receive this vaccination.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2010 Issue 1, Copyright © 2010 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
This version first published online:
July 23. 2001 AbstractBackgroundInfection with Streptococcus pneumoniae is an important cause of pneumonia and other serious illnesses, particularly amongst those with certain high-risk medical conditions such as asthma. Although pneumococcal vaccine is routinely advocated for people with asthma, there is uncertainty about the evidence base that underpins this recommendation. ObjectivesTo determine the efficacy of pneumococcal vaccine in reducing mortality or morbidity from pneumococcal disease in asthmatics. Search strategyRandomised controlled trials were identified from the Cochrane Airways Group Specialised Register of trials. Searches were current as of August 2009. Selection criteriaRandomised controlled trials, with or without blinding, in which pneumococcal vaccine has been compared with placebo or no treatment in people with clinician diagnosed asthma. Data collection and analysisTwo reviewers independently reviewed all abstracts and full papers of all articles of potential relevance were retrieved. Methodological quality was rated using the Cochrane approach and the Jadad rating scale. Data extraction was performed by one reviewer and checked independently by a second. We planned to perform quantitative analyses of outcomes on an intention-to-treat basis, where possible. Main resultsOf the three papers retrieved, only one satisfied the inclusion criteria and the methodological quality of this study was low (unblinded and inadequate allocation concealment). None of the data could be aggregated in a meta-analysis. Comparisons in a sub-set of 30 asthmatic children prone to recurrent episodes of otitis media, showed that pneumococcal vaccination decreased the incidence of acute asthma exacerbations from 10 to 7 (per child per year). A further search conducted in August 2009 did not yield any further studies. Authors' conclusionsThis review found very limited evidence to support the routine use of pneumococcal vaccine in people with asthma. A randomised trial of vaccine efficacy in children and adults with asthma is needed. |