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Lobeline for smoking cessationStead LF, Hughes JR
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SummaryNo evidence from trials that Lobeline can help people quit smokingLobeline is an alkaloid derived from the leaves of an Indian tobacco plant, and has been widely used in commercial smoking remedies. Its adverse effects include dizziness, nausea, and vomiting, and tablets and pastilles containing Lobeline may lead to throat irritation. The review found no adequate longterm trials which could provide evidence that Lobeline can help people stop smoking. Even short-term studies do not indicate a consistent effect on smoking behaviour.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2008 Issue 3, Copyright © 2008 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
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July 21. 1997 AbstractBackgroundLobeline is a partial nicotine agonist, which has been used in a variety of commercially available preparations to help stop smoking. ObjectivesThe objective of this review was to assess the effects of lobeline on long term smoking cessation. Search strategyWe searched the Cochrane Tobacco Addiction Group trials register (most recent search April 2006). Selection criteriaRandomized trials comparing lobeline to placebo or an alternative therapeutic control, which reported smoking cessation with at least six months follow-up. Data collection and analysisWe extracted data in duplicate on the type of subjects, the dose and form of lobeline, the outcome measures, method of randomisation, and completeness of follow-up. Main resultsWe identified no trials meeting the full inclusion criteria including long term follow-up. Authors' conclusionsThere is no evidence available from long term trials that lobeline can aid smoking cessation. |