|
The Cochrane Collaboration
Cochrane Reviews |
| Explore | New + Updated | Other languages |
|
 |
Antibiotics for gonorrhoea in pregnancyBrocklehurst P
Bookmark this:
     more ...
SummaryAntibiotics for gonorrhoea in pregnancyPregnant women with gonorrhoea who take penicillin, spectinomycin or ceftriaxone are much less likely to show signs of infection. Neisseria gonorrhoeae is a bacteria transmitted (passed) during sex, causing an infection in the genital area. Pregnant women with gonorrhoea may pass the infection to babies during birth. This can affect the baby's eyesight, causing blindness. The review of trials found evidence that pregnant women who take penicillin, spectinomycin, ceftriaxone or cefixime are much less likely to have signs of gonorrhoea a week to 10 days later. Further research is needed to find out which antibiotic treatment is the best for preventing infection of the baby.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2010 Issue 1, Copyright © 2010 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
This version first published online:
January 20. 1997 AbstractBackgroundNeisseria gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infection. It can also cause endometritis and pelvic sepsis in the mother. ObjectivesThe objective of this review was to assess the effects of antibiotic regimens in the treatment of genital infection with gonorrhoea during pregnancy with respect to neonatal and maternal morbidity. Search strategyWe searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 June 2009). Selection criteriaRandomized trials of one regimen of antibiotic versus another in pregnant women with culture confirmed genital gonococcal infection. Data collection and analysisEligibility and trial quality were assessed by one review author. Main resultsTwo trials involving 346 women were included. The only outcome included in these trials was the incidence of 'cure' assessed by bacterial culture. Failure to achieve 'microbiological cure' was similar for each antibiotic regimen: amoxicillin plus probenecid compared with spectinomycin (Peto odds ratio (Peto OR) 2.29, 95% confidence interval (CI) 0.74 to 7.08), amoxicillin plus probenecid compared with ceftriaxone (Peto OR 2.29, 95% CI 0.74 to 7.08) and ceftriaxone compared with cefixime (Peto OR 1.22, 95% CI 0.16 to 9.01). Side-effects were uncommon for all the tested regimens. Authors' conclusionsThe number of women included in each of the comparisons is small and therefore, although no differences were detected between the different antibiotic regimens, the trials were limited in their ability to detect important but modest differences. For women who are allergic to penicillin, this review provides some reassurance that treatment with ceftriaxone or spectinomycin appears to have similar effectiveness in producing microbiological cure. |