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Titles

ID No.: PMA1
COCHRANE TITLE: Pravastatin for coronary artery disease
OTHER TITLE: The Prospective Pravastatin Pooling Project
COLLABORATIVE GROUP: The PPP Collaborators
CONTACT DETAILS: John Simes, NHMRC Clinical Trials Centre, The University of Sydney, Australia.
PRIMARY OBJECTIVES: To examine the effects of pravastatin on total mortality and on cause-specific mortality.
SECONDARY OBJECTIVES: To examine the effects of pravastatin on total coronary events within sub-populations: primary vs secondary prevention, the elderly, men and women, patients with diabetes, current smokers, patients receving antihypertensive treatment, and categories of patients with specific baseline lipid levels.
OUTCOME MEASURES: Total deaths, CAD deaths, non-CAD deaths, cancer, trauma.
STATUS: PMA protocol published. Individual trials complete - waiting publication.
PUBLICATIONS:
a) The PPP Project Investigators. Design, rationale and baseline characteristics of the Prospective Pravastatin Poolin (PPP) Project. A combined analysis of three large-scale randomised trials - Long-term Intervention with Pravastatin in Ischemic Disease (LIPID), Cholesterol and Recurrent Events (CARE), and West of Scotland Coronary Prevention Study (WOSCOPS). American Journal of Cardiology. 1995; 76:899-905.
b) Simes RJ. Prospective meta-analysis of cholesterol-lowering studies: the Prospective Pravastatin Pooling (PPP) Project and the Cholesterol Treatment Trialists (CTT) Collaboration. American Journal of Cardiology 1995; 76:122c-126c.
SPONSOR: Nil.
PEER-REVIEW DETAILS: Submitted via the PMA MG.
DATE PMA REGISTERED: Protocol published November 1995.


ID No.: PMA2
COCHRANE TITLE: Gonadotrophin releasing hormone antagonists in assisted reproduction
OTHER TITLE: GnRHantagonists in assisted reproduction
COLLABORATIVE GROUP: Menstrual Disorders Subfertility Group
CONTACT DETAILS: Hesham Al-Inany, Cairo University, Cairo, Egypt
PRIMARY OBJECTIVE: To compare the efficacy of gonadotrophin-releasing hormone (GnRH) agonists with the standard long protocol of GnRH agonists for controlled ovarian hyperstimulation in assisted conception.
OUTCOME MEASURES: Prevention of premature LH stage, Pregnancy rate per woman, Pregnancy rate per cycle as determined by serum B-hCG and ultrasound examination for foetal heart activity, Number of oocyte retrieved per cycle, Pregnancy rate per oocyte retrieval, Pregnancy rate per embryo transfer, Spontaneous miscarriage rate, E2 level on day of hCG, Duration of GnRH analogue treatment, Amount of gonadotrophins used, Incidence of ovarian hyperstimulation syndrome, Cost effectiveness as determined by the amount of gonadoptrophin units used and cost / pregnancy.
STATUS: Protocol and review have been published.
PUBLICATIONS:
Al-Inany H, Aboulghar M. Gonadotrophin-releasing hormone antagonists for assisted conception (Cochrane Review). In: The Cochrane Library, Issue 4, 2002. Oxford: Update Software.
SPONSOR: Nil.
PEER_REVIEW DETAILS: Submitted via the PMA MG.
DATE PMA REGISTERED: Protocol published 1999. PMA registered January 2003.

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