Probiotics for the prevention or treatment of hyperbilirubinaemia in late preterm and term neonates

  • To determine the safety and efficacy of probiotics supplementation in preventing hyperbilirubinaemia among late preterm (born at gestational age (GA) 34 weeks to 36 weeks and six days) and term neonates (≥ 37 weeks)
  • To determine the safety and efficacy of probiotics supplementation in treating hyperbilirubinaemia among late preterm (born at 34 weeks to 36 weeks and six days) and term neonates (≥ 37 weeks)

Subgroup analyses will include gestational age at birth (term vs late preterm), cause of jaundice (haemolytic vs non-haemolytic jaundice), mode of feeding at the time of enrolment (exclusive breastfeeding vs mixed feeding/formula feeding), and types of probiotics used.

This is a protocol.

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