Dexmedetomidine for analgesia and sedation in newborn infants receiving mechanical ventilation

To determine the overall effectiveness and safety of dexmedetomidine for sedation and analgesia in newborn infants receiving mechanical ventilation compared with other non-opioids, opioids or placebo.

We will perform subgroup analyses according to method of dexmedetomidine administration; dose of dexmedetomidine; age of initiation of dexmedetomidine; indication for mechanical ventilation; gestational age; and duration of treatment.

This is a protocol.

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