The objectives of this review are:
- to determine the effectiveness of pharmacological interventions for the prevention of acute postoperative pain in adult participants undergoing brain surgery;
- to determine how the evaluated interventions compare in terms of other clinically important outcomes including, sedative effects, additional analgesic requirements, incidence of chronic headache, length of hospital stay and adverse events;
- to examine whether the above characteristics are significantly different for certain subgroups as defined below;
- to make appropriate clinical and future research recommendations based on the evaluated evidence.
This is a protocol.