Serum or plasma ferritin concentration as an index of iron deficiency and overload

  • To determine the diagnostic accuracy of ferritin concentrations (serum or plasma) for detecting iron deficiency
  • To determine the diagnostic accuracy of ferritin concentrations (serum or plasma) for detecting iron overload in primary and secondary iron loading syndromes
  • To determine the diagnostic accuracy of ferritin to determine iron deficiency at current WHO cut-off values (WHO 2011b): <12 ng/mL <15 ng/mL and <30 ng/mL; as well as other commonly utilised cut-offs
  • To assess the diagnostic accuracy of ferritin to determine iron overload at putative cut-off values such as 150ng/mL in females and 200 ng/mL in males (Bacon 2011; WHO 2001); 200 ng/mL and 300 ng/mL in males and females (Brissot 2009), and 500 ng/mL in mild iron overload (Brissot 2009)

This is a protocol.

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