Rapid diagnostic tests for bacterial meningitis applicable in sub-Saharan Africa

  1. To determine the sensitivity and specificity of each identified RDT for each organism it can detect.
  2. To determine the sensitivity and specificity by serogroup of each identified N. meningitidis RDT.

We will separately analyse each of these for tests performed under laboratory or field conditions.

To assess differences between the accuracy of tests performed when prevalence is low and high and in high-income or low-income countries, which are potential sources of heterogeneity. We will also assess differences in index test performance according to the reference standard used (CSF culture or PCR) and compare different tests with one another.

This is a protocol.

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