Vitamin D supplementation for prevention of vitamin D deficiency in preterm and low birth weight infants

Primary objective

To determine the effectiveness of vitamin D supplementation (daily cumulative dose ≥ 200 IU) for the prevention of vitamin D deficiency in preterm and low birth weight infants.

We will define vitamin D deficiency by clinical features (rickets, osteopenia or bone fractures), serum vitamin D levels (< 20 ng/mL) or a combination of both.

Secondary objective

To determine the safety of vitamin D supplementation (daily cumulative dose ≥ 200 IU) for the prevention of vitamin D deficiency in preterm and low birth weight infants.

This is a protocol.

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