Cerebral near-infrared spectroscopy monitoring for prevention of brain injury in very preterm infants

To evaluate the benefits and harms of interventions that alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury, improve neurological outcome, and increase survival rate in preterm infants.

In subgroup analyses, we will examine the effectiveness and safety of NIRS-guided treatments in relation to the following criteria: gestational age (GA), quality of intervention, and level of support during the first seven days of life.

This is a protocol.