The purpose of this systematic review is to identify and summarise the results of randomised controlled trials that assess the benefits and harms of transvaginal sonography or other screening measures (e.g. serum CA-125 or HE4) and multimodal testing, for ovarian cancer screening in asymptomatic postmenopausal women with an average EOC risk by evaluating the screening-related patient-relevant outcomes (e.g. EOC-specific mortality rates).