[This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the diagnostic accuracy of antigen detecting assays for diagnosing acute Dengue infections in persons living or returning from an endemic area and presen

To assess the diagnostic accuracy of commercial NS1 antigen detecting assays for acute dengue infection.

To compare the diagnostic accuracy of LFIs and ELISAs antigen detecting assays.

To explore the following potential sources of heterogeneity: degree of endemicity, continent, patient age, primary versus secondary dengue infection, serotype, type of participant (residents or traveller), and timing of sample collection from onset of symptoms.

This is a protocol.