The overall objective of the review is to evaluate the effects of non-fluoride topical remineralising agents (NFTRA-Ca/Ps) containing any formulation of calcium and/or phosphate at any concentration and in any topically-applied delivery vehicle (including but not limited to toothpastes, mouthrinses, varnish, creams, chewing gum, lozenges) for controlling caries i.e. preventing the development or progression of dental caries or promoting the arrest or reversal of caries. 

The specific objectives are to.

1. Determine the effectiveness of NFTRA-Ca/Ps alone for preventing the development or progression of dental caries or for promoting the arrest or reversal of caries compared to:
1. placebo or no treatment
2. one or more topical fluoride modalities (e.g. toothpaste, gel, varnish, mouthrinse).
2. Determine the effectiveness of NFTRA-Ca/Ps in combination with fluoride, either as a single vehicle or as separate topical vehicles, for preventing the development or progression of dental caries or for promoting the arrest or reversal of caries compared to a single topical fluoride modality or a combination of topical fluoride modalities. 
3. Determine the effectiveness of one NFTRA-Ca/P versus another, either alone or in combination with fluoride, (as described above) for preventing the development or progression of dental caries or for promoting the arrest or reversal of caries.
4. Examine if the effectiveness of NFTRA-Ca/Ps is influenced by:
1. the NFTRA-Ca/P's formulation, concentration, mode of delivery, duration or frequency of application
2. the baseline level of caries or caries risk status of the study population, age of study population (i.e. child or adult), background exposure to fluoride.
5. To determine any adverse effects associated with the use of NFTRA-Ca/Ps (e.g. nausea, bad taste, mucosal reaction, calculus build-up).