Blood pressure lowering efficacy of clonidine for primary hypertension

Primary objective

To assess the dose-related effect of clonidine as compared to placebo on systolic and diastolic blood pressure in patients with primary hypertension.

To assess the dose-related effect of clonidine as compared to placebo on systolic and diastolic blood pressure in postmenopausal women with hot flashes without hypertension

To assess the dose-related effect of clonidine as compared to placebo on systolic and diastolic blood pressure in patients treated for opoid withdrawal without hypertension

To assess the dose-related effect of clonidine as compared to placebo on systolic and diastolic blood pressure in patients treated for alcohol addiction without hypertension

Secondary objectives

To assess the dose-related effect of clonidine on heart rate.

To assess the effect of clonidine on pulse pressure.

To assess the effect of clonidine on blood pressure variability.

To assess the effect of clonidine on withdrawals due to adverse effects.

This is a protocol.

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